Filmography
| Year | Title | Role |
| 2022 | Sr. (2022) | Producer |
| 2022 | Sr. (2022) | Self |
| 2020 | Dolittle (2020) | Dr. John Dolittle |
| 2019 | Avengers: Endgame (2019) | Tony Stark/Iron Man |
| 2018 | Avengers: Infinity War (2018) | Tony Stark/Iron Man |
| 2017 | Marvel Studios 10th: Spider-Man: Homecoming: The IMAX Experience | Tony Stark/Iron Man |
| 2016 | Captain America: Civil War (2016) | Tony Stark/Iron Man |
| 2015 | Avengers: Age of Ultron (2015) | Tony Stark/Iron Man |
| 2014 | The Judge (2014) | Hank Palmer |
| 2014 | Chef (2014) | Marvin |
| 2013 | Iron Man 3 (2013) | Tony Stark/Iron Man |
| 2012 | Marvel Studios 10th: The Avengers: An IMAX 3D Experience | Tony Stark/Iron Man |
| 2011 | Sherlock Holmes: A Game of Shadows | Sherlock Holmes |
| 2010 | Due Date | Peter Highman |
| 2010 | Iron Man 2 (2010) | Tony Stark/Iron Man |
| 2009 | The Soloist | Steve Lopez |
| 2008 | Tropic Thunder | Kirk Lazarus |
| 2008 | Iron Man (2008) | Tony Stark/Iron Man |
| 2007 | Charlie Bartlett | Principal Gardner |
| 2007 | Zodiac | Paul Avery |
| 2006 | A Guide to Recognizing Your Saints | Dito |
| 2006 | The Shaggy Dog (2006) | Marcus Kozak |
| 2006 | A Scanner Darkly | Barris |
| 2006 | Fur: An Imaginary Portrait of Diane Arbus | Lionel Sweeney |
| 2005 | Kiss Kiss, Bang Bang (2005) | Harry Lockhart |
| 2005 | Game 6 | Steven Schwimmer |
| 2005 | Good Night, and Good Luck | Joe Wershba |
| 2005 | Hubert Selby Jr.: It'll Be Better Tomorrow | Narrator |
| 2004 | Eros | Nick Penrose (segment "Equilibrium") |
| 2003 | The Singing Detective | Dan Dark |
| 2003 | Gothika | Pete Graham |
| 2000 | Wonder Boys | Terry Crabtree |
| 1999 | Black and White (1999) | Terry |
| 1999 | Bowfinger | Jerry Renfro |
| 1999 | In Dreams | Vivian Thompson |
| 1998 | The Gingerbread Man | Clyde Pell |
| 1997 | Two Girls and a Guy | Blake Allen |
| 1995 | Restoration (1994) | Robert Merivel |
| 1995 | Home for the Holidays | Tommy Larson |
| 1994 | Natural Born Killers | Wayne Gale |
| 1994 | Hail Caesar (1994) | Jerry |
| 1993 | Short Cuts | Bill Bush |
| 1993 | Heart and Souls | Thomas Reilly |
| 1992 | Chaplin | Charles Chaplin |
| 1991 | Soapdish | David Seton Barnes |
| 1990 | Air America | Billy Covington |
| 1989 | Chances Are | Alex Finch |
| 1989 | True Believer | Roger Baron |
| 1988 | Miss Mary | Leo Wiggins |
| 1988 | 1969 | Ralph Carr |
| 1987 | Less Than Zero | Julian Wells |
| 1987 | The Pick-Up Artist | Jack Jericho |
| 1986 | Back to School | Derek Lutz |
| 1985 | Weird Science | Ian |
| 1975 | Moment to Moment (1975) | Actor |
