Filmography
| Year | Title | Role |
| 2024 | Lilly (2025) | Actor |
| 2022 | She Said (2022) | Rebecca Corbett |
| 2022 | Causeway (2022) | Executive Producer |
| 2022 | Monica (2023) | Eugenia |
| 2018 | Maze Runner: The Death Cure | Ava Paige |
| 2018 | Out of Blue | Detective Mike Hoolihan |
| 2018 | Jonathan (2018) | Dr. Mina Nariman |
| 2017 | The Party (2018) | April |
| 2017 | The Bookshop | Violet Gamart |
| 2015 | Maze Runner: The Scorch Trials | Ava Paige |
| 2014 | The Maze Runner (2014) | Ava Paige |
| 2014 | Regarding Susan Sontag | Narrator |
| 2014 | Last Weekend | Celia |
| 2014 | October Gale | Helen Matthews |
| 2014 | Learning to Drive | Wendy |
| 2013 | The East (2013) | Sharon |
| 2011 | Friends With Benefits | Lorna |
| 2011 | One Day | Alison |
| 2010 | Calle Mayor | Willa |
| 2010 | Shutter Island | Rachel Salondo 2 |
| 2010 | Easy A | Rosemary Penderghast |
| 2010 | Legendary | Sharon Chetley |
| 2009 | Whatever Works | Marietta |
| 2009 | Cairo Time | Juliette Grant |
| 2008 | Elegy | Carolyn |
| 2008 | Blind Date | Janna |
| 2008 | Phoebe in Wonderland | Miss Dodger |
| 2008 | Vicky Cristina Barcelona | Judy Nash |
| 2007 | No Reservations | Paula |
| 2007 | Lars and the Real Girl | Dagmar |
| 2007 | Married Life | Pat |
| 2007 | For the Love of Movies: The Story of American Film Criticism | Narrator |
| 2006 | All the King's Men (2006) | Sadie Burke |
| 2005 | Good Night, and Good Luck | Shirley Wershba |
| 2005 | The Dying Gaul | Elaine |
| 2004 | Miracle (2004) | Mrs. Brooks |
| 2003 | All the Real Girls | Elvira Fine |
| 2003 | Dogville | Vera |
| 2003 | The Station Agent | Olivia Harris |
| 2003 | Pieces of April | Joy Burns |
| 2002 | Welcome to Collinwood | Rosalind |
| 2002 | Heartbreak Hospital | Lottie Ohrwasher |
| 2002 | Far From Heaven | Eleanor Fine |
| 2002 | The Baroness and the Pig | The Baroness |
| 2002 | Carrie (2002) | Margaret White |
| 2001 | The Pledge | Margaret Larsen |
| 2001 | Wendigo | Kim |
| 2001 | The Safety of Objects | Annette Jennings |
| 2000 | Joe Gould’s Secret | Vivian Marquie |
| 1999 | The Green Mile | Melinda Moores |
| 1998 | High Art (1998) | Greta |
| 1992 | Blind Man's Bluff | Dr. Virginia Hertz |
| 1990 | Tune in Tomorrow... | Aunt Olga |
