Filmography
| Year | Title | Role |
| 2023 | Nyad (2023) | Bonnie Stoll |
| 2021 | The Mauritanian | Nancy Hollander |
| 2018 | Hotel Artemis | The Nurse |
| 2018 | Be Natural: The Untold Story of Alice Guy-Blaché | Executive Producer, Narrator |
| 2016 | Money Monster | Director |
| 2013 | Elysium | Delacourt |
| 2011 | The Beaver | Meredith Black |
| 2011 | Carnage (2011) | Penelope Longstreet |
| 2009 | Motherhood | Self |
| 2008 | Nim's Island | Alexandra Rover |
| 2007 | The Brave One | Erica Bain |
| 2006 | Inside Man (2006) | Madaline White |
| 2005 | Flightplan | Kyle Pratt |
| 2004 | A Very Long Engagement | Elodie Gordes |
| 2002 | Panic Room | Meg Altman |
| 2002 | The Dangerous Lives of Altar Boys | Sister Assumpta |
| 2000 | Waking The Dead | Executive Producer |
| 1999 | Anna and the King | Anna Leonowens |
| 1998 | The Baby Dance | Executive Producer |
| 1995 | Home for the Holidays | Director, Producer |
| 1994 | Maverick (1994) | Annabelle Bransford |
| 1992 | Shadows and Fog | Prostitute |
| 1991 | The Silence of the Lambs | Clarice Starling |
| 1991 | Little Man Tate | Dede Tate |
| 1988 | Stealing Home | Katie Chandler |
| 1987 | Five Corners | Linda |
| 1984 | Mesmerized | Victoria |
| 1984 | The Hotel New Hampshire | Frannie Berry |
| 1980 | Foxes | Jeanie |
| 1977 | Candleshoe | Casey Brown |
| 1976 | Taxi Driver (1976) | Iris |
| 1976 | Freaky Friday (1976) | Annabel Andrews |
| 1976 | Bugsy Malone | Tallulah |
| 1976 | The Little Girl Who Lives Down the Lane | Rynn |
| 1974 | Alice Doesn't Live Here Anymore | Audrey |
| 1973 | Tom Sawyer | Becky Thatcher |
| 1972 | Kansas City Bomber | Rita |
| 1972 | Napoleon and Samantha | Samantha |
