Filmography
| Year | Title | Role |
| 2023 | Fast X (2023) | Cipher |
| 2022 | The School for Good and Evil (2022) | Lady Lesso |
| 2021 | F9 The Fast Saga (2021) | Cipher |
| 2021 | The Addams Family 2 (2021) | Morticia Addams |
| 2019 | Long Shot | Charlotte Field |
| 2019 | The Addams Family (2019) | Morticia Addams |
| 2019 | Bombshell (2019) | Megyn Kelly |
| 2018 | Gringo (2018) | Elaine Markinson |
| 2018 | Tully (2018) | Marlo |
| 2018 | A Private War | Producer |
| 2017 | The Fate of the Furious | Cipher |
| 2017 | Atomic Blonde | Lorraine Broughton |
| 2016 | The Huntsman: Winter's War | Ravenna |
| 2016 | Kubo and the Two Strings | Monkey |
| 2016 | The Last Face (2017) | Wren |
| 2015 | Mad Max: Fury Road | Imperator Furiosa |
| 2015 | Dark Places | Libby Day |
| 2014 | A Million Ways to Die in the West | Anna |
| 2013 | Angels in Exile | Narrator |
| 2012 | Snow White and the Huntsman | Ravenna |
| 2012 | Prometheus | Meredith Vickers |
| 2011 | Young Adult | Mavis Gary |
| 2009 | The Road (2009) | Wife |
| 2009 | Astro Boy | "Our Friends" Narrator |
| 2008 | Hancock | Mary Embrey |
| 2008 | The Burning Plain | Sylvia |
| 2008 | Ferris Wheel | Joleen |
| 2007 | In the Valley of Elah | Det. Emily Sanders |
| 2007 | Battle in Seattle | Ella |
| 2006 | East of Havana | Producer |
| 2005 | Aeon Flux | Aeon Flux |
| 2005 | North Country | Josey Aimes |
| 2004 | Head in the Clouds | Gilda Bessé |
| 2004 | The Life and Death of Peter Sellers | Britt Ekland |
| 2003 | Monster (2003) | Aileen Wuornos |
| 2003 | The Italian Job (2003) | Stella Bridger |
| 2002 | Waking Up in Reno | Candy |
| 2001 | Sweet November | Sara Deever |
| 2001 | 15 Minutes | Rose Hearn |
| 2001 | The Curse of the Jade Scorpion | Laura Kensington |
| 2000 | Reindeer Games | Ashley |
| 2000 | The Yards | Erica Stoltz |
| 2000 | The Legend of Bagger Vance | Adele Invergordon |
| 2000 | Men of Honor | Gwen |
| 1999 | The Cider House Rules | Candy Kendall |
| 1999 | The Astronaut's Wife | Jillian Armacost |
| 1998 | Mighty Joe Young | Jill Young |
| 1997 | The Devil's Advocate | Mary Ann Lomax |
| 1996 | That Thing You Do! | Tina |
