Filmography
| Year | Title | Role |
| 2025 | The Alto Knights (2025) | Frank Costello/Vito Genovese |
| 2025 | Megadoc (2025) | Self |
| 2025 | Tin Soldier (2025) | Emmanuel Ashburn |
| 2024 | Henry Fonda for President (2024) | Actor |
| 2023 | About My Father (2023) | Salvo |
| 2023 | Killers of the Flower Moon (2023) | William Hale |
| 2023 | Ezra (2024) | Actor, Executive Producer |
| 2022 | Amsterdam (2022) | Actor |
| 2022 | Savage Salvation (2022) | Sheriff Church |
| 2020 | The War with Grandpa | Ed |
| 2020 | The Comeback Trail (2025) | Max Barber |
| 2019 | Joker (2019) | Murray Franklin |
| 2019 | The Irishman (2019) | Frank Sheeran |
| 2016 | Dirty Grandpa | Dick Kelly |
| 2016 | Hands of Stone | Ray Arcel |
| 2016 | The Comedian | Jackie Burke |
| 2015 | Heist | The Pope |
| 2015 | The Intern | Ben |
| 2015 | Joy (2015) | Rudy |
| 2015 | Ellis | Narrator |
| 2014 | Remembering the Artist: Robert De Niro, Sr. | Self |
| 2014 | The Bag Man | Dragna |
| 2013 | The Big Wedding | Don |
| 2013 | Last Vegas | Paddy |
| 2013 | Grudge Match | Billy "The Kid" McDonnen |
| 2013 | American Hustle | Victor Tellegio |
| 2013 | Killing Season | Benjamin Ford |
| 2012 | Being Flynn | Jonathan Flynn |
| 2012 | Silver Linings Playbook | Pat Sr. |
| 2012 | Red Lights | Simon Silver |
| 2012 | Freelancers | Joe Sarcone |
| 2011 | Limitless | Carl Van Loon |
| 2011 | Killer Elite | Hunter |
| 2011 | NEW YEAR'S EVE EVENT | Stan Harris |
| 2010 | Little Fockers | Jack Byrnes |
| 2010 | Machete | Sen. McLaughlin |
| 2009 | Tout va bien | Frank |
| 2009 | I Knew It Was You: Rediscovering John Cazale | Actor |
| 2008 | What Just Happened | Ben |
| 2008 | Righteous Kill | Detective Thomas Cowan |
| 2007 | Stardust | Captain Shakespeare |
| 2007 | Mr. Warmth: The Don Rickles Project | Actor |
| 2006 | The Good Shepherd | Bill Sullivan |
| 2005 | Rent (2005) | Producer |
| 2004 | Godsend | Dr. Richard Wells |
| 2004 | Stage Beauty | Producer |
| 2004 | Meet the Fockers | Jack Byrnes |
| 2004 | Shark Tale | Don Lino |
| 2004 | The Bridge of San Luis Rey | The Archbishop |
| 2002 | City by the Sea | Detective Vincent Lamarca |
| 2002 | Showtime | Mitch Preston |
| 2002 | Analyze That | Paul Vitti |
| 2002 | About a Boy | Producer |
| 2002 | 9/11 (2002) | Actor |
| 2001 | 15 Minutes | Eddie Fleming |
| 2001 | The Score | Nick Wells |
| 2001 | Prison Song | Producer |
| 2000 | The Adventures of Rocky and Bullwinkle | Fearless Leader |
| 2000 | Meet the Parents | Jack Byrnes |
| 2000 | Men of Honor | Billy Sunday |
| 1999 | Analyze This | Boss Paul Vitti |
| 1999 | Flawless (1999) | Walt Koontz |
| 1998 | Ronin | Sam |
| 1998 | GREAT EXPECTATIONS | Prisoner Arthur Lustig |
| 1997 | Jackie Brown | Louis Gara |
| 1997 | Cop Land | Lt. Moe Tilden |
| 1997 | Wag the Dog | Conrad Brean |
| 1996 | Sleepers | Father Bobby |
| 1996 | Marvin's Room | Dr. Wally |
| 1996 | The Fan | Gil Renard |
| 1995 | One Hundred and One Nights | Le mari de la star-fantasme en croisière |
| 1995 | Casino (1995) | Sam 'Ace' Rothstein |
| 1995 | Heat (1995) | Neil McCauley |
| 1994 | Mary Shelley's Frankenstein | The Creature |
| 1993 | A Bronx Tale (1993) | Lorenzo Anello |
| 1993 | Mad Dog and Glory | Wayne `'Mad Dog'` Dobie |
| 1993 | This Boy's Life | Dwight Hansen |
| 1992 | Night and the City (1992) | Harry Fabian |
| 1992 | Thunderheart | Producer |
| 1991 | Cape Fear (1991) | Max Cady |
| 1991 | Guilty by Suspicion | David Merrill |
| 1991 | Backdraft | Donald 'Shadow' Rimgale |
| 1991 | Hearts of Darkness: A Filmmaker's Apocalypse | Actor |
| 1990 | Goodfellas | James "Jimmy" Conway |
| 1990 | Awakenings | Leonard Lowe |
| 1990 | Stanley & Iris | Stanley Everett Cox |
| 1988 | Midnight Run | Jack Walsh |
| 1987 | The Untouchables | Al Capone |
| 1987 | Angel Heart | Louis Cyphre |
| 1986 | The Mission (1986) | Rodrigo Mendoza |
| 1985 | Brazil | Archibald "Harry" Tuttle |
| 1984 | A Father... a Son...Once Upon a Time in Hollywood | David 'Noodles' Aaronson |
| 1983 | The King of Comedy (1983) | Rupert Pupkin |
| 1981 | True Confessions | Des Spellacy |
| 1980 | Raging Bull | Jake La Motta |
| 1978 | The Deer Hunter | Michael Vronsky |
| 1977 | New York, New York (1977) | Jimmy Doyle |
| 1976 | Taxi Driver (1976) | Travis Bickle |
| 1976 | The Last Tycoon | Monroe Stahr |
| 1976 | 1900 | Alfredo Berlinghieri |
| 1976 | The Cinema According to Bertolucci | Actor |
| 1974 | The Godfather, Part II (1975) | Vito Corleone |
| 1973 | Mean Streets | Johnny Boy Cervello |
| 1973 | Bang the Drum Slowly | Bruce Pearson |
| 1971 | The Gang That Couldn't Shoot Straight | Mario |
| 1970 | Hi, Mom | Jon Rubin |
| 1970 | Bloody Mama | Lloyd Barker |
| 1969 | The Wedding Party | Cecil |
| 1968 | Greetings | Jon Rubin |
