Filmography
| Year | Title | Role |
| 2022 | Halloween Ends (2022) | Laurie Strode |
| 2022 | Everything Everywhere All at Once (2022) | |
| 2021 | Halloween Kills (2021) | Laurie Strode |
| 2019 | Knives Out | Linda Drysdale |
| 2018 | Halloween (2018) | Laurie Strode |
| 2017 | Hondros | |
| 2014 | Veronica Mars | Gayle Buckley |
| 2011 | From Up on Poppy Hill | Ryoko (English language version) |
| 2010 | You Again | Gail |
| 2009 | Dirt! The Movie | Narrator |
| 2008 | Not Quite Hollywood: The Wild, Untold Story of Ozploitation | |
| 2008 | Beverly Hills Chihuahua | Aunt Viv |
| 2005 | The Kid & I | Herself |
| 2004 | Christmas with the Kranks | Nora Krank |
| 2003 | Freaky Friday | Tess Coleman |
| 2002 | Halloween: Resurrection | Laurie Strode |
| 2001 | The Tailor of Panama | Louisa Pendel |
| 2001 | Rudolph and the Island of Misfit Toys | Queen Camilla |
| 2000 | Drowning Mona | Rona Mace |
| 1998 | Halloween H2O: 20 Years Later | Laurie Strode/ Keri Tate |
| 1998 | Homegrown | Sierra Kahan |
| 1996 | House Arrest (2012) | Janet Beindorf |
| 1995 | The Heidi Chronicles | Heidi Holland |
| 1994 | True Lies | Helen Tasker |
| 1992 | Forever Young (1992) | Claire |
| 1991 | My Girl | Shelly DeVoto |
| 1990 | Blue Steel | Megan Turner |
| 1988 | A Fish Called Wanda | Wanda Gerschwitz |
| 1988 | Dominick and Eugene | Jennifer Reston |
| 1987 | Amazing Grace and Chuck | Lynn Taylor |
| 1986 | As Summers Die | Whitsey Loftin |
| 1983 | Trading Places | Ophelia |
| 1983 | Love Letters | Anna |
| 1981 | Halloween II (1981) | Laurie Strode |
| 1981 | Escape From New York (1981) | Narration and Computer Voice |
| 1980 | The Fog | Elizabeth Solley |
| 1980 | Terror Train | Alana |
| 1978 | Halloween (1978) | Laurie |