Filmography
| Year | Title | Role |
| 2025 | Marty Supreme (2025) | Actor |
| 2019 | Avengers: Endgame (2019) | Pepper Potts |
| 2018 | Avengers: Infinity War (2018) | Pepper Potts |
| 2017 | Man in Red Bandana | Narrator |
| 2017 | Marvel Studios 10th: Spider-Man: Homecoming: The IMAX Experience | Pepper Potts |
| 2015 | Mortdecai | Johanna Mortdecai |
| 2013 | Iron Man 3 (2013) | Pepper Potts |
| 2012 | Thanks for Sharing | Phoebe |
| 2012 | Marvel Studios 10th: The Avengers: An IMAX 3D Experience | Pepper Potts |
| 2011 | Contagion | Beth Emhoff |
| 2010 | Iron Man 2 (2010) | Pepper Potts |
| 2010 | Country Strong | Kelly Canter |
| 2008 | Iron Man (2008) | Virginia "Pepper" Potts |
| 2008 | Two Lovers | Michelle Rausch |
| 2007 | The Good Night | Dora |
| 2006 | Infamous (2006) | Kitty Dean |
| 2006 | Running with Scissors | Hope |
| 2006 | Love and Other Disasters | Hollywood Jacks |
| 2005 | Proof | Catherine |
| 2005 | I've Come to Tell You I'm Going | Actor |
| 2004 | Sky Captain and the World of Tomorrow | Polly Perkins |
| 2003 | View From the Top | Donna Jensen |
| 2003 | Sylvia | Sylvia Plath |
| 2002 | Possession (2002) | Maud Bailey |
| 2001 | Shallow Hal | Rosemary |
| 2001 | The Royal Tenenbaums | Margot Tenenbaum |
| 2000 | Duets | Liv |
| 2000 | Bounce | Abby |
| 1999 | The Talented Mr. Ripley | Marge Sherwood |
| 1998 | A Perfect Murder | Emily Bradford Taylor |
| 1998 | Shakespeare in Love | Viola De Lesseps |
| 1998 | Sliding Doors | Helen Quilley |
| 1998 | GREAT EXPECTATIONS | Estella |
| 1996 | Hard Eight | Clementine |
| 1996 | Emma (1996) | Emma Woodhouse |
| 1996 | The Pallbearer | Julie DeMarco |
| 1995 | Jefferson in Paris | Patsy Jefferson |
| 1995 | Se7en | Tracy Mills |
| 1994 | Mrs. Parker and the Vicious Circle | Paula Hunt |
| 1993 | Flesh and Bone | Ginnie |
| 1993 | Malice (1993) | Paula Bell |
| 1992 | Cruel Doubt | Angela Pritchard |
