Filmography
| Year | Title | Role |
| 2024 | Juror #2 (2024) | Director, Producer |
| 2021 | Cry Macho (2021) | Mike Milo |
| 2021 | Ennio (2024) | Self |
| 2019 | Richard Jewell | Director, Producer |
| 2018 | The 15:17 to Paris | Director, Producer |
| 2018 | The Mule (2018) | Earl Stone |
| 2017 | SAD HILL UNEARTHED | Actor |
| 2016 | Sully | Director |
| 2014 | Jersey Boys | Director, Producer |
| 2014 | American Sniper | Director |
| 2013 | Milius | Self |
| 2013 | WCFF-EASTWOOD DIRECTS | Actor |
| 2012 | Trouble With the Curve | Gus Lobel |
| 2011 | J. Edgar | Director, Original Music, Producer |
| 2010 | Hereafter (2010) | Director, Original Music, Producer |
| 2009 | Invictus | Director, Producer |
| 2009 | Johnny Mercer: The Dreams on Me | Actor |
| 2008 | Changeling | Director |
| 2008 | Gran Torino | Walt Kowalski |
| 2008 | You Must Remember This: The Warner Bros. Story | Narrator |
| 2007 | Mr. Warmth: The Don Rickles Project | Actor |
| 2006 | Flags of Our Fathers | Director, Original Music, Producer |
| 2006 | Letters from Iwo Jima | Director |
| 2004 | Million Dollar Baby | Frankie Dunn |
| 2003 | Mystic River | Director, Music, Producer |
| 2002 | Blood Work | Terry McCaleb |
| 2000 | Space Cowboys | Frank Corvin |
| 1999 | Forever Hollywood (1999) | Self |
| 1999 | True Crime | Steve Everett |
| 1997 | Midnight in the Garden of Good and Evil | Director, Producer |
| 1997 | Absolute Power | Luther Whitney |
| 1995 | One Hundred and One Nights | Self |
| 1995 | The Bridges of Madison County | Robert Kincaid |
| 1995 | The Stars Fell on Henrietta | Producer |
| 1995 | A Personal Journey With Martin Scorsese Through American Movies | Self |
| 1993 | A Perfect World | Chief Red Garnett |
| 1993 | In the Line of Fire | Frank Horrigan |
| 1992 | Unforgiven | William 'Bill' Munny |
| 1990 | White Hunter, Black Heart | John Wilson |
| 1990 | The Rookie (1990) | Nick Pulovski |
| 1988 | Thelonious Monk: Straight, No Chaser | Executive Producer |
| 1988 | Bird (1988) | Director, Producer |
| 1986 | Heartbreak Ridge | Sergeant Thomas Highway |
| 1985 | Pale Rider | Preacher |
| 1984 | Tightrope | Wes Block |
| 1984 | City Heat | Lieutenant Speer |
| 1983 | Sudden Impact | Insp. 'Dirty' Harry Callahan |
| 1982 | Honkytonk Man | Red Stovall |
| 1982 | Firefox | Mitchell Gant |
| 1980 | Any Which Way You Can | Philo Beddoe |
| 1980 | Bronco Billy | Bronco Billy |
| 1979 | Escape from Alcatraz | Frank Morris |
| 1978 | Every Which Way But Loose | Philo Beddoe |
| 1977 | The Gauntlet | Ben Shockley |
| 1976 | The Outlaw Josey Wales | Josey Wales |
| 1976 | The Enforcer | Insp. 'Dirty' Harry Callahan |
| 1975 | The Eiger Sanction | Dr. Jonathan Hemlock |
| 1974 | Thunderbolt and Lightfoot | Thunderbolt |
| 1973 | Magnum Force | Insp. "Dirty" Harry Callahan |
| 1973 | High Plains Drifter | The Stranger |
| 1973 | Breezy | Director |
| 1972 | Joe Kidd | Joe Kidd |
| 1971 | Dirty Harry | Harry Callahan |
| 1971 | Play Misty for Me | Dave |
| 1971 | The Beguiled (1971) | John McBurney |
| 1970 | Kelly's Heroes | Pvt. Kelly |
| 1970 | Two Mules for Sister Sara | Hogan |
| 1969 | Paint Your Wagon | Sylvester Newel |
| 1969 | Where Eagles Dare | Lt. Morris Schaffer |
| 1968 | Coogan's Bluff | Coogan |
| 1968 | Hang 'Em High | Marshal Jed Cooper |
| 1967 | Le Streghe (The Witches) | Actor |
| 1966 | The Good, the Bad and the Ugly | Blondie |
| 1965 | For a Few Dollars More | Monco |
| 1964 | A Fistful of Dollars | Joe |
| 1958 | Lafayette Escadrille | George Moseley |
| 1956 | The First Traveling Saleslady | Lt. Jack Rice |
| 1955 | Revenge of the Creature | Jennings |
| 1955 | Tarantula | Jet Squadron Leader |
| 1955 | Francis in the Navy | Jonesey |
