Filmography
| Year | Title | Role |
| 2025 | F1 The Movie (2025) | Sonny Hayes |
| 2025 | Mickey 17 (2025) | Executive Producer |
| 2025 | Anemone (2025) | Executive Producer |
| 2025 | It's Never Over, Jeff Buckley (2025) | Executive Producer |
| 2025 | Preparation for the Next Life (2025) | Executive Producer |
| 2025 | Hedda (2025) | Executive Producer |
| 2024 | Bob Marley: One Love (2024) | Executive Producer |
| 2024 | Beetlejuice Beetlejuice (2024) | Executive Producer |
| 2024 | Nickel Boys (2024) | Executive Producer |
| 2024 | Wolfs (2024) | Pam's Man |
| 2023 | Landscape with Invisible Hand (2023) | Executive Producer |
| 2022 | The Lost City (2022) | Jack Trainer |
| 2022 | Bullet Train (2022) | Ladybug |
| 2022 | She Said (2022) | Executive Producer |
| 2022 | Babylon (2022) | Jack Conrad |
| 2022 | Blonde (2022) | Producer |
| 2020 | Irresistible (2020) | Executive Producer |
| 2020 | Kajillionaire | Executive Producer |
| 2020 | Minari (2021) | Executive Producer |
| 2019 | Once Upon a Time in Hollywood | Cliff Booth |
| 2019 | The Last Black Man in San Francisco | Executive Producer |
| 2019 | Ad Astra | Roy McBride |
| 2019 | The King (2019) | Producer |
| 2018 | Beautiful Boy (2018) | Producer |
| 2018 | If Beale Street Could Talk | Executive Producer |
| 2018 | Vice (2018) | Producer |
| 2017 | War Machine | Gen. Glen McMahon |
| 2017 | Okja | Executive Producer |
| 2017 | Brad's Status | Executive Producer |
| 2016 | Voyage of Time: The IMAX Experience (2016) | Actor |
| 2016 | Voyage of Time: The IMAX Experience | Narrator, Producer |
| 2016 | Moonlight (2016) | Executive Producer |
| 2016 | Allied | Max Vatan |
| 2016 | Voyage of Time: Life's Journey | Producer |
| 2016 | The Lost City of Z | Executive Producer |
| 2015 | True Story | Executive Producer |
| 2015 | By the Sea | Roland |
| 2015 | The Big Short | Ben Rickert |
| 2015 | Hitting the Apex | Narrator, Producer |
| 2014 | Fury (2014) | Don "Wardaddy" Collier |
| 2014 | The Normal Heart | Executive Producer |
| 2014 | Selma | Executive Producer |
| 2013 | World War Z | Gerry Lane |
| 2013 | Kick-Ass 2 | Producer |
| 2013 | The Counselor | Westray |
| 2013 | 12 Years a Slave | Bass |
| 2013 | Big Men | Executive Producer |
| 2012 | Killing Them Softly | Jackie Cogan |
| 2011 | Moneyball | Billy Beane |
| 2011 | The Tree of Life | Mr. O'Brien |
| 2011 | His Way | Self |
| 2011 | Happy Feet Two in 3D | Will the Krill |
| 2010 | Megamind | Metro Man |
| 2010 | Kick-Ass | Producer |
| 2010 | Eat Pray Love | Executive Producer |
| 2009 | The Time Traveler's Wife | Executive Producer |
| 2009 | Inglourious Basterds | Lt. Aldo Raine |
| 2009 | The Private Lives of Pippa Lee | Executive Producer |
| 2008 | The Curious Case of Benjamin Button | Benjamin Button |
| 2008 | Burn After Reading | Chad Feldheimer |
| 2007 | The Assassination of Jesse James by the Coward Robert Ford | Jesse James |
| 2007 | Ocean's Thirteen | Rusty Ryan |
| 2007 | Year of the Dog (2007) | Executive Producer |
| 2007 | A Mighty Heart | Producer |
| 2006 | Running with Scissors | Producer |
| 2006 | The Departed | Producer |
| 2006 | God Grew Tired of Us | Executive Producer |
| 2005 | Mr. & Mrs. Smith (2005) | John Smith |
| 2004 | Troy | Achilles |
| 2004 | Ocean's Twelve | Rusty Ryan |
| 2003 | Sinbad: Legend of the Seven Seas | Sinbad |
| 2002 | Full Frontal | Brad / Himself |
| 2002 | Confessions of a Dangerous Mind | Bachelor n. 1 |
| 2001 | The Mexican | Jerry Welbach |
| 2001 | Spy Game | Tom Bishop |
| 2001 | Ocean's Eleven (1960) | Rusty Ryan |
| 2000 | Snatch | One Punch' Mickey ONeil |
| 1999 | Fight Club (1999) | Tyler Durden |
| 1998 | Meet Joe Black | Joe Black |
| 1997 | The Devil's Own | Rory Devaney / Francis Austin McGuire |
| 1997 | Seven Years in Tibet | Heinrich Harrer |
| 1996 | Sleepers | Michael Sullivan |
| 1995 | 12 Monkeys | Jeffrey Goines |
| 1995 | Se7en | Detective David Mills |
| 1994 | Interview With the Vampire | Louis de Pointe du Lac |
| 1994 | Legends of the Fall | Tristan Ludlow |
| 1993 | True Romance | Floyd |
| 1993 | Kalifornia | Early Grayce |
| 1992 | A River Runs Through It | Paul Maclean |
| 1992 | Cool World (1992) | Detective Frank Harris |
| 1991 | Thelma & Louise | J.D. |
| 1991 | Across the Tracks | Joe Maloney |
| 1991 | Johnny Suede | Johnny Suede |
| 1989 | Cutting Class | Dwight Ingalls |
| 1988 | The Dark Side of the Sun | Rick |
