Filmography
| Year | Title | Role |
| 2026 | THE BRIDE! (2026) | Dr. Euphronious |
| 2023 | Nyad (2023) | Diana Nyad |
| 2023 | Poolman (2024) | Diane |
| 2022 | Death on the Nile (2022) | Euphemia |
| 2019 | Captain Marvel (2019) | Supreme Intelligence/Dr. Wendy Lawson |
| 2019 | The Report (2019) | Senator Dianne Feinstein |
| 2019 | Hope Gap | Grace |
| 2019 | A Towering Task: The Story of the Peace Corps | Narrator |
| 2019 | Georgetown (2021) | Amanda Brecht |
| 2018 | The Seagull (2018) | Irina Arkadina |
| 2018 | Life Itself (2018) | Dr. Cait Morris |
| 2017 | Film Stars Don't Die in Liverpool | Gloria Grahame |
| 2016 | Rules Don't Apply | Lucy Mabrey |
| 2016 | 20th Century Women | Dorothea |
| 2015 | Danny Collins | Mary Sinclair |
| 2014 | The Search | Helen |
| 2013 | The Face of Love | Nikki |
| 2012 | Ruby Sparks | Gertrude |
| 2012 | Girl Most Likely | Zelda |
| 2012 | Ginger & Rosa | Bella |
| 2011 | Yogawoman | Narrator |
| 2010 | The Kids Are All Right | Nic |
| 2009 | Mother and Child | Karen |
| 2008 | The Women (2008) | Sylvie Fowler |
| 2007 | 14 Women | Narrator |
| 2006 | Running with Scissors | Deirdre Burroughs |
| 2004 | Being Julia | Julia Lambert |
| 2003 | Open Range | Sue Barlow |
| 2000 | What Planet Are You | Susan |
| 1999 | American Beauty (1999) | Carolyn Burnham |
| 1999 | Forever Hollywood (1999) | Self |
| 1999 | In Dreams | Claire Cooper |
| 1996 | Mars Attacks! | Barbara Land |
| 1995 | The American President | Sydney Ellen Wade |
| 1991 | Bugsy | Virginia Hill |
| 1991 | Guilty by Suspicion | Ruth Merrill |
| 1990 | The Grifters | Myra Langtry |
| 1990 | Postcards From the Edge | Evelyn Ames |
| 1989 | Valmont | Merteuil |
| 1988 | The Great Outdoors | Kate Craig |
