Filmography
| Year | Title | Role |
| 2025 | The King of Kings (2025) | Catherine Dickens |
| 2024 | Oh, Canada (2024) | Emma/Gloria |
| 2023 | Red, White & Royal Blue (2023) | Ellen Claremont |
| 2023 | The Kill Room (2023) | Patrice |
| 2020 | The War with Grandpa | Sally |
| 2018 | The Con is On | Harriet Fox |
| 2018 | The House That Jack Built (2018) | Lady 1 |
| 2018 | Down a Dark Hall | Madame Duret |
| 2017 | Kalachakra: The Enlightenment | Narrator |
| 2015 | Burnt | Simone |
| 2014 | Nymphomaniac: Volume I | Mrs. H |
| 2013 | Movie 43 | Fake Lois Lane |
| 2012 | Playing for Keeps | Patti |
| 2012 | Bel Ami | Madeleine Forestier |
| 2012 | Love, Marilyn | Actor |
| 2010 | Ceremony | Zoe |
| 2010 | Percy Jackson & the Olympians: The Lightning Thief | Medusa |
| 2009 | Motherhood | Eliza Welsh |
| 2008 | The Accidental Husband | Emma |
| 2007 | In Bloom | Diana |
| 2006 | My Super Ex-Girlfriend | Jenny/G-Girl |
| 2006 | Kill Bill: The Whole Bloody Affair | The Bride/Beatrix Kiddo (Archive Footage) |
| 2005 | Prime (2005) | Rafi Gardet |
| 2005 | The Producers (2005) | Ulla |
| 2005 | Be Cool | Edie Athens |
| 2004 | Kill Bill: Vol. 2 | Beatrix Kiddo - The Bride, 'Black Mamba' |
| 2003 | Kill Bill: Vol. 1 | The Bride/Black Mamba |
| 2003 | Paycheck | Rachel Porter |
| 2002 | Hysterical Blindness | Debby Miller |
| 2001 | Tape (2001) | Amy |
| 2001 | Chelsea Walls | Grace |
| 2000 | Vatel | Anne de Montausier |
| 2000 | The Golden Bowl | Charlotte Stant |
| 1999 | Sweet and Lowdown | Blanche |
| 1998 | Les Misérables (1998) | Fantine |
| 1997 | Batman & Robin | Dr. Pamela Isley/Poison Ivy |
| 1997 | Gattaca | Irene Cassini |
| 1996 | The Truth About Cats & Dogs | Noelle |
| 1996 | Beautiful Girls | Andera |
| 1994 | Pulp Fiction | Mia Wallace |
| 1993 | Even Cowgirls Get the Blues | Sissy Hankshaw |
| 1993 | Mad Dog and Glory | Glory |
| 1990 | Henry & June | June Miller |
| 1989 | The Adventures of Baron Munchausen | Venus/Rose |
| 1988 | Miss Mary | Georgia Elkans |
| 1988 | Dangerous Liaisons (1988) | Cécile de Volanges |
| 1984 | Nausicaa of the Valley of the Wind | Kushana |
