Filmography
| Year | Title | Role |
| 2025 | Night Always Comes (2025) | Doreen |
| 2023 | Poolman (2024) | Actor |
| 2022 | Sharp Stick (2022) | Actor |
| 2019 | QT8: The First Eight | Self |
| 2018 | Annihilation (2018) | Dr. Ventress |
| 2018 | White Boy Rick | FBI Agent Snyder |
| 2017 | Amityville: The Awakening | Joan |
| 2017 | Good Time | Corey |
| 2016 | Morgan | Dr. Kathy Grieff |
| 2016 | LBJ | Lady Bird Johnson |
| 2015 | Anomalisa | Lisa |
| 2015 | Feast: THE HATEFUL EIGHT | Daisy Domergue |
| 2014 | Me | Jennifer |
| 2014 | Alex of Venice | Maureen |
| 2014 | Welcome to Me | Deb Moseley |
| 2013 | The Spectacular Now | Sara |
| 2013 | The Moment (2014) | Lee |
| 2013 | Kill Your Darlings | Naomi Ginsberg |
| 2013 | Hateship Loveship | Ken's Girlfriend |
| 2013 | Jake Squared | Sheryl |
| 2010 | Greenberg | Beth |
| 2008 | Synecdoche, New York | Maria |
| 2007 | Margot at the Wedding | Pauline |
| 2005 | The Jacket | Dr. Lorenson |
| 2005 | Rag Tale | Actor |
| 2004 | The Machinist | Stevie |
| 2004 | Palindromes | 'Mark' Aviva |
| 2004 | Childstar | Suzanne |
| 2003 | In the Cut | Pauline |
| 2002 | Road to Perdition | Jennifer Sullivan |
| 2002 | Hey Arnold! The Movie | Bridget |
| 2001 | The Anniversary Party | Sally Therrian |
| 2000 | The King Is Alive | Gina |
| 1999 | eXistenZ | Allegra Geller |
| 1997 | Washington Square | Catherine Sloper |
| 1996 | Kansas City | Blondie O'Hara |
| 1996 | Bastard Out of Carolina | Anney Boatwright |
| 1995 | Georgia | Sadie Flood |
| 1995 | Dolores Claiborne | Selena St. George |
| 1994 | The Hudsucker Proxy | Amy Archer |
| 1994 | Mrs. Parker and the Vicious Circle | Dorothy Parker |
| 1993 | Short Cuts | Lois Kaiser |
| 1993 | Luck, Trust and Ketchup: Robert Altman in Carver Country | Actor |
| 1992 | Single White Female | Hedra 'Hedy' Carlson |
| 1991 | Backdraft | Jennifer Vaitkus |
| 1991 | Rush (1991) | Kristen Cates |
| 1990 | Miami Blues | Susie Waggoner |
| 1989 | Last Exit to Brooklyn | Tralala |
| 1989 | The Big Picture (1989) | Lydia Johnson |
| 1986 | The Hitcher (1986) | Nash |
| 1985 | Flesh & Blood | Agnes |
| 1983 | Easy Money (1983) | Allison Capuletti |
| 1982 | Fast Times at Ridgemont High | Stacy Hamilton |
| 1982 | Wrong Is Right | Young Girl |
| 1981 | The Best Little Girl in the World | Casey Powell |
