Filmography
| Year | Title | Role |
| 2019 | Arctic Dogs | Lemmy |
| 2019 | Zeroville | Vikar |
| 2018 | Kin (2018) | Taylor Balik |
| 2018 | Future World | Warlord |
| 2018 | The Ballad of Buster Scruggs | Cowboy (Segment "Near Algodones") |
| 2018 | The Pretenders | Director |
| 2018 | Pretenders | Maxwell |
| 2017 | High School Lover | Rick Winters |
| 2017 | The Institute (2017) | Dr. Cairn |
| 2017 | The Disaster Artist (2017) | Tommy Wiseau |
| 2017 | The Vault (2017) | Ed Maas |
| 2017 | Voices Beyond the Wall | Executive Producer |
| 2017 | The Heyday of the Insensitive Bastards | Conrad |
| 2017 | Don't Come Back From the Moon | Roman Smalley |
| 2017 | Obey Giant | Executive Producer |
| 2017 | Tenn | Director |
| 2016 | Sausage Party | Druggie |
| 2016 | Why Him? | Laird Mayhew |
| 2016 | Goat (2016) | Mitch |
| 2016 | Memoria (2016) | Mr. Wyckoff |
| 2016 | King Cobra | Joe |
| 2016 | Burn Country | Lindsay |
| 2016 | In Dubious Battle | Mac |
| 2015 | Yosemite | Phil |
| 2015 | True Story | Christian Longo |
| 2015 | Wild Horses | Ben Briggs |
| 2015 | The Little Prince | The Fox |
| 2015 | I Am Michael | Michael Glatze |
| 2015 | The Night Before | Self |
| 2015 | HFF 15: F For Franco | Self |
| 2015 | Every Thing Will Be Fine | Tomas Eldan |
| 2015 | The Adderall Diaries | Stephen Elliott |
| 2015 | Queen of the Desert | Henry Cadogan |
| 2014 | Good People | Tom |
| 2014 | The Interview (2014) | Dave Skylark |
| 2014 | National Theater Live: Of Mice and Men - Encore | Actor |
| 2014 | The Sound & the Fury | Benjy Compson |
| 2014 | I Think You're Totally Wrong: A Quarrel | James |
| 2013 | Kink | Executive Producer, Producer |
| 2013 | Oz The Great and Powerful | Oscar Diggs/Oz |
| 2013 | Lovelace | Hugh Hefner |
| 2013 | This Is the End | Self |
| 2013 | Interior. Leather Bar. | James |
| 2013 | Homefront | Gator |
| 2013 | As I Lay Dying | Darl Bundren |
| 2013 | Mademoiselle C | Self |
| 2013 | Child of God | Jerry |
| 2013 | Third Person | Rick |
| 2013 | Palo Alto | Mr. B |
| 2012 | Marina Abramovic: The Artist Is Present | Actor |
| 2012 | Maladies | James |
| 2012 | Francophrenia | Director |
| 2012 | About Cherry | Francis |
| 2012 | The Iceman (2013) | Marty |
| 2012 | The Color of Time | C.K. Williams |
| 2012 | A24 x IMAX Present: Spring Breakers (2025) | Alien |
| 2011 | Your Highness | Fabious |
| 2011 | Rise of the Planet of the Apes | Will Rodman |
| 2011 | Eames: The Architect & the Painter | Narrator |
| 2011 | The Broken Tower | Hart Crane |
| 2011 | Sal | Milton Katselas |
| 2010 | Date Night | Taste |
| 2010 | Eat Pray Love | David Piccolo |
| 2010 | Howl | Allen Ginsberg |
| 2010 | 127 Hours | Aron Ralston |
| 2010 | Shadows and Lies | William |
| 2010 | The Clerk's Tale | Director, Screenwriter |
| 2008 | Camille (2007) | Silias |
| 2008 | Nights in Rodanthe | Mark |
| 2008 | Pineapple Express | Saul Silver |
| 2008 | Erased James Franco | Actor |
| 2007 | In the Valley of Elah | Sgt. Carnelli |
| 2007 | Finishing the Game | Rob Force |
| 2007 | An American Crime | Andy |
| 2007 | Good Time Max | Max |
| 2007 | Spider-Man 3 (Fathom 2025) | Harry Osborn/New Goblin |
| 2006 | Annapolis | Jake Huard |
| 2006 | Tristan & Isolde | Tristan |
| 2006 | Flyboys (2006) | Blaine Rawlings |
| 2006 | The Dead Girl | Derek |
| 2005 | The Great Raid | Captain Prince |
| 2004 | Spider-Man 2.1 (Fathom 2025) | Harry Osborn |
| 2003 | The Company | Josh |
| 2002 | Deuces Wild | Tino |
| 2002 | City by the Sea | Joey LaMarca |
| 2002 | Sonny | Sonny |
| 2002 | Mother Ghost | Skateboarder guy |
| 2002 | Spider-Man (Fathom 2025) | Harry Osborn |
| 2001 | James Dean | James Dean/Narrator |
| 2000 | Whatever It Takes | Chris Campbell |
