Filmography
| Year | Title | Role |
| 1995 | A Personal Journey With Martin Scorsese Through American Movies | Himself (archive footage) |
| 1961 | Pocketful of Miracles | Director, Producer |
| 1959 | A Hole in the Head | Director, Producer |
| 1958 | The Unchained Goddess | Producer, Screenwriter |
| 1951 | Here Comes the Groom | Director, Producer |
| 1948 | State of the Union | Director, Producer |
| 1946 | It's a Wonderful Life (1946) | Director, Producer, Writer |
| 1945 | Two Down and One to Go | Director |
| 1945 | Know Your Enemy (1945) | Director, Producer, Screenwriter |
| 1945 | War Comes to America | Director, Producer |
| 1945 | Here Is Germany | Director, Producer, Screenwriter |
| 1944 | Arsenic and Old Lace (1969) | Director, Producer |
| 1944 | The Negro Soldier | Producer |
| 1943 | The Battle of Russia | Director, Producer |
| 1943 | Divide and Conquer (1943) | Director |
| 1943 | The Nazis Strike | Director |
| 1943 | The Battle of Britain | Director, Producer |
| 1942 | Prelude to War | Director, Producer |
| 1941 | Meet John Doe | Director, Producer |
| 1939 | Mr. Smith Goes to Washington (1939) | Director, Producer |
| 1938 | You Can't Take It With You | Director |
| 1937 | Lost Horizon (1937) | Director, Producer |
| 1936 | Mr. Deeds Goes to Town | Director, Producer |
| 1934 | It Happened One Night | Director, Executive Producer, Producer |
| 1934 | Broadway Bill | Director |
| 1933 | The Bitter Tea of General Yen | Director |
| 1933 | Lady for a Day | Director |
| 1932 | American Madness | Director |
| 1932 | Forbidden (1932) | Director, Producer |
| 1931 | Platinum Blonde | Director |
| 1931 | The Miracle Woman | Director |
| 1931 | Dirigible | Director |
| 1930 | Ladies of Leisure | Director |
| 1930 | Rain or Shine | Director |
| 1929 | Younger Generation | Director |
| 1929 | The Donovan Affair | Director |
| 1928 | That Certain Thing | Director, Producer, Screenwriter |
| 1928 | Submarine (1928) | Director |
| 1928 | The Matinee Idol | Director |
| 1927 | His First Flame | Screenwriter |
| 1927 | Long Pants | Director |
| 1926 | The Strong Man | Director |
| 1926 | Tramp, Tramp, Tramp | Screenwriter |
| 1926 | Saturday Afternoon Shorts | Screenwriter |
| 1925 | Boobs in the Woods | Screenwriter |
