Filmography
| Year | Title | Role |
| 2025 | Being Eddie (2025) | Self |
| 2024 | Beverly Hills Cop: Axel F (2024) | Axel Foley |
| 2023 | You People (2023) | Akbar |
| 2023 | Candy Cane Lane (2023) | Actor, Producer |
| 2021 | Coming to America Quote-Along | Prince Akeem/Clarence/Saul/Randy Watson |
| 2019 | Dolemite Is My Name | Rudy Ray Moore |
| 2016 | Mr. Church | Henry Joseph Church |
| 2012 | A Thousand Words | Jack McCall |
| 2011 | Tower Heist | Slide |
| 2010 | Shrek Forever After | Donkey |
| 2009 | Imagine That | Evan Danielson |
| 2008 | Meet Dave | Dave/Captain |
| 2007 | Shrek the Third | Donkey |
| 2007 | Norbit | Norbit/Rasputia/Mr. Wong |
| 2007 | Shrek the Halls | Donkey |
| 2006 | Dreamgirls | James `Thunder' Early |
| 2004 | Shrek 2 | Donkey |
| 2003 | Daddy Day Care | Charlie Hinton |
| 2003 | The Haunted Mansion | Jim Evers |
| 2002 | Showtime | Trey Sellars |
| 2002 | The Adventures of Pluto Nash | Pluto Nash |
| 2002 | I Spy | Kelly Robinson |
| 2001 | Shrek (2001) | Donkey |
| 2001 | Dr. Dolittle 2 | Dr. Dolittle |
| 2000 | The Nutty Professor 2 - The Klumps | Professor Sherman Klump/Clesius "Papa" Klump/Young Clesius Klump/Mama Klump/Ernie Klump/Grandma Klump/Buddy Love/Lance Perkins |
| 1999 | Life (1999) | Rayford Gibson |
| 1999 | Bowfinger | Kit Ramsey/Jiffernson 'Jiff' Ramsey |
| 1998 | Mulan (1998) | Mushu |
| 1998 | Dr. Dolittle (1998) | Dr. John Dolittle |
| 1997 | Metro | Insp. Scott Roper |
| 1996 | The Nutty Professor (1996) | Professor Sherman Klump/Buddy Love/Lance Perkins/Cletus 'Papa' Klump/Anna Pearl 'Mama' Jensen Klump/Ida Mae 'Granny' Jensen/Ernie Klump, Sr. |
| 1995 | Vampire in Brooklyn | Maximilian/Preacher Pauly/Guido |
| 1994 | Sure Thing: BEVERLY HILLS COP | Det. Axel Foley |
| 1992 | Boomerang (1992) | Marcus |
| 1990 | Another 48 HRS. | Reggie Hammond |
| 1989 | Harlem Nights | Quick |
| 1988 | Coming to America (1988) | Prince Akeem/Clarence/Randy Watson/Saul |
| 1987 | Eddie Murphy Raw | Executive Producer, Self, Writer |
| 1987 | Beverly Hills Cop II | Det. Axel Foley |
| 1986 | The Golden Child | Chandler Jarrell |
| 1984 | Beverly Hills Cop | Det. Axel Foley |
| 1983 | Trading Places | Billy Ray Valentine |
| 1983 | 48 HRS. | Reggie Hammond |
