Filmography
| Year | Title | Role |
| 2026 | Ready or Not 2: Here I Come (2026) | Actor |
| 2024 | The Shrouds (2025) | Director, Screenwriter |
| 2022 | Crimes of the Future (2022) | Director, Screenwriter |
| 2019 | Disappearance at Clifton Hill | Walter |
| 2014 | Maps to the Stars | Director |
| 2013 | Tales From the Organ Trade | Narrator |
| 2012 | Cosmopolis | Director, Screenwriter |
| 2011 | A Dangerous Method | Director |
| 2010 | William S. Burroughs: A Man Within | Actor |
| 2007 | Eastern Promises (2007) | Director |
| 2005 | A History of Violence | Director |
| 2005 | The Best of Secter & the Rest of Secter | Actor |
| 2002 | Jason X | Dr. Wimmer |
| 2002 | Spider (1945) | Director, Screenwriter |
| 2000 | American Night | Self |
| 1999 | eXistenZ | Director, Producer, Writer |
| 1998 | Last Night (1998) | Duncan |
| 1996 | Crash (1996) | Director, Producer, Writer |
| 1995 | Blood & Donuts | Crime boss |
| 1993 | M. Butterfly | Director |
| 1991 | Naked Lunch | Director, Writer |
| 1990 | Nightbreed | Dr. Philip K. Decker |
| 1988 | Dead Ringers (1988) | Director, Producer, Screenwriter |
| 1986 | The Fly (1986) | Gynecologist |
| 1985 | Into the Night | Group Supervisor |
| 1983 | Videodrome | Director, Writer |
| 1983 | The Dead Zone (1983) | Director |
| 1981 | Scanners | Director, Writer |
| 1979 | The Brood | Director, Screenwriter |
| 1979 | Fast Company | Director |
| 1977 | Rabid (1977) | Director, Screenwriter |
| 1975 | Shivers | Director, Writer |
| 1970 | Crimes of the Future (1970) | Cinematographer, Director, Film Editing, Producer, Writer |
| 1969 | Stereo | Director, Producer, Writer |
