Filmography
| Year | Title | Role |
| 2025 | Couture (2026) | Maxine |
| 2024 | Maria (2024) | Maria Callas |
| 2021 | Eternals (2021) | Thena |
| 2021 | Those Who Wish Me Dead (2021) | Hannah |
| 2020 | Come Away | Rose Littleton |
| 2019 | Maleficent: Mistress of Evil | Maleficent |
| 2017 | The Breadwinner (2017) | Producer |
| 2017 | First They Killed My Father: A Daughter of Cambodia Remembers | Director |
| 2016 | Kung Fu Panda 3 | Tigress |
| 2015 | By the Sea | Vanessa |
| 2014 | Maleficent | Maleficent |
| 2014 | Unbroken (2014) | Director |
| 2014 | Difret | Executive Producer |
| 2011 | Kung Fu Panda 2 | Tigress |
| 2011 | In the Land of Blood and Honey | Director, Producer, Screenwriter |
| 2010 | The Tourist | Elise Clifton-Ward |
| 2010 | Jane's Journey | Self |
| 2008 | Changeling | Christine Collins |
| 2008 | Wanted (2008) | Fox |
| 2008 | Kung Fu Panda | Master Tigress |
| 2008 | The Day After Peace | Actor |
| 2007 | Beowulf | Grendel's Mother |
| 2007 | A Mighty Heart | Mariane Pearl |
| 2007 | A Place in Time | Director |
| 2006 | The Good Shepherd | Clover/Margaret Russell |
| 2005 | Mr. & Mrs. Smith (2005) | Jane Smith |
| 2005 | Trudell | Executive Producer |
| 2004 | Taking Lives | Illeana |
| 2004 | Sky Captain and the World of Tomorrow | Capt. Francesca 'Franky' Cook |
| 2004 | Shark Tale | Lola |
| 2004 | The Fever | Revolutionary |
| 2003 | Lara Croft: Tomb Raider: The Cradle of Life | Lara Croft |
| 2003 | Beyond Borders | Sarah Jordan |
| 2003 | Alexander (2004) | Olympias |
| 2002 | Life or Something Like It | Lanie |
| 2001 | Original Sin | Julia Russell/Bonny Castle |
| 2001 | Lara Croft: Tomb Raider Le Film | Lara Croft |
| 2000 | Gone in Sixty Seconds | Sara "Sway" Wayland |
| 1999 | Girl, Interrupted | Lisa |
| 1999 | The Bone Collector | Amelia Donaghy |
| 1999 | Pushing Tin | Mary Bell |
| 1995 | Hackers | Kate Libby/"Acid Burn" |
| 1995 | Without Evidence | Jodie Sweringen |
