Filmography
| Year | Title | Role |
| 2025 | Mission: Impossible - The Final Reckoning (2025) | Erika Sloane |
| 2024 | Damsel (2024) | Lady Bayford |
| 2022 | Black Panther: Wakanda Forever (2022) | Ramonda |
| 2022 | Good Night Oppy (2022) | Narrator |
| 2022 | Wendell & Wild (2022) | Sister Helley |
| 2020 | Soul (2020) | Dorothea |
| 2019 | Otherhood | Carol Walker |
| 2019 | The Apollo | Self |
| 2018 | Black Panther (2018) | Ramonda |
| 2018 | Mission: Impossible - Fallout | Erika Sloane |
| 2018 | Bumblebee | Shatter |
| 2016 | London Has Fallen | Lynn Jacobs |
| 2015 | Survivor | Maureen Crane |
| 2015 | Chi-Raq | Miss Helen |
| 2014 | White Bird in a Blizzard | Dr. Thaler |
| 2013 | Olympus Has Fallen | Secret Service Director Lynn Jacobs |
| 2013 | Black Nativity | Aretha Cobbs |
| 2013 | Betty & Coretta | Coretta Scott King |
| 2012 | This Means War | Collins |
| 2011 | Green Lantern | Dr. Waller |
| 2011 | Jumping the Broom | Mrs. Watson |
| 2009 | Notorious (2009) | Voletta Wallace |
| 2009 | Why We Laugh: Black Comedians on Black Comedy | Narrator |
| 2008 | Nothing But the Truth | Bonnie Benjamin |
| 2008 | Tyler Perry's Meet the Browns | Brenda |
| 2008 | Of Boys and Men | Rieta Cole |
| 2008 | Gospel Hill | Sarah Malcolm |
| 2007 | Meet the Robinsons | Mildred |
| 2006 | Akeelah and the Bee | Tanya |
| 2005 | Mr. & Mrs. Smith (2005) | Mr. Smith's Boss |
| 2004 | Mr. 3000 | Mo |
| 2004 | The Lazarus Child | Dr. Elizabeth Chase |
| 2003 | Masked and Anonymous | Mistress |
| 2002 | Sunshine State | Desiree Perry |
| 2002 | Our America | Executive Producer |
| 2001 | The Score | Diane |
| 2000 | Boesman and Lena | Lena |
| 2000 | Whispers: An Elephant's Tale | Groove |
| 1999 | Music of the Heart | Janet Williams |
| 1999 | Our Friend, Martin | Miles' Mom |
| 1998 | How Stella Got Her Groove Back | Stella Payne |
| 1995 | Strange Days | Lornette "Mace" Mason |
| 1995 | Waiting to Exhale | Bernadine 'Bernie' Harris |
| 1995 | Vampire in Brooklyn | Det. Rita Veder |
| 1993 | What's Love Got to Do with It? (1993) | Tina Turner |
| 1992 | Malcolm X | Betty Shabazz |
| 1992 | Passion Fish | Rhonda / Dawn |
| 1991 | Boyz N the Hood | Reva Devereaux |
| 1991 | City of Hope | Reesha |
