- Eddie Murphy
- Professor Sherman Klump/Clesius "Papa" Klump/Young Clesius Klump/Mama Klump/Ernie Klump/Grandma Klump/Buddy Love/Lance Perkins, Executive Producer
- Janet Jackson
- Professor Denise Gaines, Original Music
- Larry Miller
- Dean Richmond
- John Ales
- Jason
- Richard Gant
- Mr. Gaines
- Anna Maria Horsford
- Mrs. Gaines
- Melinda McGraw
- Leanne Guilford
- Jamal Mixon
- Ernie Klump Jr.
- Gabriel Williams
- Isaac
- Peter Segal
- Director
- Steve Oedekerk
- Writer
- Barry W. Blaustein
- Screenwriter, Writer
- David Sheffield
- Screenwriter, Writer
- Paul Weitz
- Screenwriter
- Chris Weitz
- Screenwriter
- James D. Brubaker
- Executive Producer
- Michael Ewing
- Co-Producer
- Brian Grazer
- Producer
- Arlene Kehela
- Associate Producer
- Karen Kehela Sherwood
- Executive Producer
- Jerry Lewis
- Executive Producer
- Eddie Murphy
- Professor Sherman Klump/Clesius "Papa" Klump/Young Clesius Klump/Mama Klump/Ernie Klump/Grandma Klump/Buddy Love/Lance Perkins, Executive Producer
- Tom Shadyac
- Executive Producer
- James Whitaker
- Co-Producer
- Janet Jackson
- Professor Denise Gaines, Original Music
- David Newman
- Original Music
- Dean Semler
- Cinematographer
- William Kerr
- Film Editing
- Pamela Basker
- Casting
- Joanne Koehler
- Casting
- William A. Elliott
- Production Design
- Greg Papalia
- Art Director
- John Anderson
- Set Decoration
- Sharen Davis
- Costume Design
- Rick Baker
- Special Makeup Effects Artist
- Kerry Mendenhall
- Hair Stylist
