- Keanu Reeves
- Neo/Thomas Anderson
- Carrie-Anne Moss
- Trinity/Tiffany
- Yahya Abdul-Mateen II
- Morpheus/Agent Smith
- Jonathan Groff
- Smith
- Jessica Henwick
- Bugs
- Neil Patrick Harris
- The Analyst
- Jada Pinkett Smith
- Niobe
- Priyanka Chopra Jonas
- Sati
- Christina Ricci
- Gwyn de Vere
- Lambert Wilson
- The Merovingian
- Andrew Lewis Caldwell
- Jude
- Toby Onwumere
- Sequoia
- Max Riemelt
- Sheperd
- Joshua Grothe
- FunktIøn
- Brian J. Smith
- Berg
- Eréndira Ibarra
- Lexy
- Michael X. Sommers
- Skroce
- L. Trey Wilson
- Hanno
- Mumbi Maina
- Ellster
- Max Mauff
- Quillion
- Purab Kohli
- Zen
- Freema Agyeman
- Astra
- Sabrina Strehl
- Fiona
- Andrew Rothney
- Scott
- Cooper Rivers
- GJ
- Daniel Bernhardt
- Agent Johnson
- Andrew Caldwell
- Jude
- Chad Stahelski
- Chad
- Julian Grey
- Brandon
- Ellen Hollman
- Echo
- Lana Wachowski
- Director, Producer, Screenwriter
- David Mitchell
- Screenwriter
- Aleksandar Hemon
- Screenwriter
- James McTeigue
- Producer
- Grant Hill
- Producer
- Garrett Grant
- Executive Producer
- Terry Needham
- Executive Producer
- Michael Salven
- Executive Producer
- Karin Wachowski
- Executive Producer
- Jesse Ehrman
- Executive Producer
- Bruce Berman
- Executive Producer
- Daniele Massaccesi
- Cinematographer
- John Toll
- Cinematographer
- Joseph Jett Sally
- Film Editor
- Johnny Klimek
- Original Music
- Tom Tykwer
- Original Music
- Hugh Bateup
- Production Design
- Richard Bloom
- Art Director
- Lisa Brennan
- Set Decoration
- Lindsay Pugh
- Costume Designer
- Carmen Cuba
- Casting
- Peter Walpole
- Production Design
