- Jordana Brewster
- Delilah Profitt
- Clea Duvall
- Stokely "Stokes" Mitchell
- Laura Harris
- Marybeth Louise Hutchinson
- Josh Hartnett
- Zeke Tyler
- Shawn Hatosy
- Stan Rosado
- Salma Hayek
- Nurse Rosa Harper
- Famke Janssen
- Miss Elizabeth Burke
- Piper Laurie
- Mrs. Karen Olson
- Christopher McDonald
- Frank Connor
- Bebe Neuwirth
- Principal Valerie Drake
- Robert Patrick
- Coach Joe Willis
- Usher
- Gabe Santora
- Jon Stewart
- Prof. Edward Furlong
- Daniel von Bargen
- John Tate
- Elijah Wood
- Casey Connor
- Susan Willis
- Jessica Brummel
- Louis Black
- Mr. Lewis
- Dannie Helen Loraine Knowles
- Tatooed Pierced Girl #2 (uncredited)
- Harry Jay Knowles
- Mr. Knowles
- Jarrell Jay Knowles
- Football Fan (uncredited)
- Duane Martin
- Cop #1 (uncredited)
- Jason May
- Biology Student (uncredited)
- Ray Melendez
- Student (uncredited)
- Eric Vespe
- Geek (uncredited)
- Wiley Wiggins
- F... Up #2
- Katherine Willis
- Officer #2
- Robert Rodriguez
- Director, Producer
- David Wechter
- Writer
- Bruce Kimmel
- Writer
- Kevin Williamson
- Screenwriter
- Elizabeth Avellan
- Producer
- Bill Scott
- Line Producer
- Tamara Smith
- Assistant Producer
- Bob Weinstein
- Executive Producer
- Harvey Weinstein
- Executive Producer
- Enrique Chediak
- Cinematographer
