- Tim Blake Nelson
- Buster Scruggs (Segment "The Ballad of Buster Scruggs")
- Willie Watson
- The Kid (Segment "The Ballad of Buster Scruggs")
- David Krumholtz
- Frenchman in Saloon (Segment "The Ballad of Buster Scruggs")
- James Franco
- Cowboy (Segment "Near Algodones")
- Stephen Root
- Teller (Segment "Near Algodones")
- Ralph Ineson
- The Man in Black (Segment "Near Algodones")
- Liam Neeson
- Impresario (Segment "Meal Ticket")
- Harry Melling
- Harrison (Segment "The Ballad of Buster Scruggs")
- Tom Waits
- Prospector (Segment "All Gold Canyon")
- Zoe Kazan
- Alice Longabaugh (Segment "The Gal Who Got Rattled")
- Bill Heck
- Billy Knapp (Segment "The Ballad of Buster Scruggs")
- Grainger Hines
- Mr. Arthur (Segment "The Gal Who Got Rattled")
- Tyne Daly
- Lady (Segment "The Mortal Remains")
- Saul Rubinek
- Frenchman (Segment "The Mortal Remains")
- Chelcie Ross
- Trapper (Segment "The Mortal Remains")
- Brendan Gleeson
- Irishman (Segment "The Mortal Remains")
- Jonjo O'Neill
- Thigpen (Segment "The Mortal Remains")
- Clancy Brown
- Curly Joe (Segment "The Ballad of Buster Scruggs")
- Jefferson Mays
- Gilbert Longabaugh (Segment "The Ballad of Buster Scruggs")
- Joel Coen
- Director, Producer, Screenwriter
- Ethan Coen
- Director, Producer, Screenwriter
- Megan Ellison
- Producer
- Sue Naegle
- Producer
- Bruno Delbonnel
- Cinematographer
- Roderick Jaynes
- Film Editing
- Carter Burwell
- Original Music
- Jess Gonchor
- Production Design
- Mary Zophres
- Costume Design
- Ellen Chenoweth
- Casting
