- Patricia Arquette
- Frankie Paige
- Gabriel Byrne
- Father Andrew Kiernan
- Jonathan Pryce
- Cardinal Daniel Houseman
- Nia Long
- Donna Chadway
- Thomas Kopache
- Father Durning
- Rade Serbedzija
- Marion Petrocelli
- Enrico Colantoni
- Father Dario
- Dick Latessa
- Father Gianni Delmonico
- Portia de Rossi
- Jennifer Kelliho
- Patrick Muldoon
- Steven
- Ann Cusack
- Dr. Reston
- Shaun Toub
- Doctor
- Tom Hodges
- E.R. Nurse
- Lydia Hazan
- Attending Nurse
- Shaun Duke Moosekian
- Dr. Eckworth
- Valarie Trapp
- Woman with a Baby
- Kessia Kordelle
- Cheryl
- Frankie Thorn
- Donna's Customer
- Mariah Nunn
- Sister Angela
- Tom Fahn
- MTA Man
- Marilyn Pitzer
- Homeless Woman
- Jack Donner
- Father Alameida
- Richard Conti
- Valet Priest
- Mary Linda Phillips
- Sister Agnes
- Liz Cruz
- Waitress
- Faith Christopher
- Waitress
- Joe Ruffo
- Guard
- Frederico Scutti
- Guard
- William Howell
- Aerialist
- Rupert Wainwright
- Director
- Tom Lazarus
- Writer
- Rick Ramage
- Writer
- Frank Mancuso Jr.
- Producer
- Chris Boardman
- Original Music
- Elia Cmiral
- Original Music
- Billy Corgan
- Original Music
- Mike Garson
- Original Music
- Michael Heinkel
- Original Music
- Sinéad O'Connor
- Original Music
- Jeffrey Kimball
- Cinematographer
- Michael J. Duthie
- Film Editing
- Michael R. Miller
- Film Editing
- Wendy Kurtzman
- Casting
- Waldemar Kalinowski
- Production Design
- Anthony Stabley
- Art Director
- Florence Fellman
- Set Decoration
- Louise Frogley
- Costume Design
