Filmography
| Year | Title | Role |
| 1967 | Guess Who's Coming to Dinner | Matt Drayton |
| 1963 | It's a Mad, Mad, Mad, Mad World | Capt. T.G. Culpeper |
| 1962 | How the West Was Won | Narrator |
| 1961 | Judgment at Nuremberg | Chief Judge Dan Haywood |
| 1961 | The Devil at 4 O'clock | Father Matthew Doonan |
| 1960 | Inherit the Wind | Henry Drummond |
| 1958 | The Old Man and the Sea (1958) | The Old Man |
| 1958 | The Last Hurrah | Mayor Frank Skeffington |
| 1957 | Desk Set (1957) | Richard Sumner |
| 1955 | Bad Day at Black Rock | John J. Macreedy |
| 1954 | Broken Lance | Matt Devereaux |
| 1953 | The Actress | Clinton Jones |
| 1952 | Pat and Mike | Mike Conovan |
| 1951 | Father's Little Dividend | Stanley Banks |
| 1951 | The People Against O'Hara | James P. Curtayne |
| 1950 | Father of the Bride (1991) | Stanley T. Banks |
| 1950 | Malaya | Carnahan |
| 1949 | Adam's Rib (1949) | Adam Bonner |
| 1949 | Edward, My Son | Arnold Boult |
| 1948 | State of the Union | Grant Matthews |
| 1947 | The Sea of Grass | Col. James B. "Jim" Brewton |
| 1947 | Cass Timberlane | Cass Timberlane |
| 1945 | Without Love | Pat Jamieson |
| 1944 | The Seventh Cross | George Heisler |
| 1944 | Thirty Seconds Over Tokyo | Lieutenant Colonel James H. Doolittle |
| 1943 | A Guy Named Joe | Pete Sandidge |
| 1942 | Keeper of the Flame | Steven "Stevie" O'Malley |
| 1942 | Woman of the Year | Sam Craig |
| 1942 | Tortilla Flat | Pilon |
| 1941 | Dr. Jekyll and Mr. Hyde (1941) | Dr. Henry Jekyll/Mr. Hyde |
| 1940 | Northwest Passage | Maj. Robert Rogers |
| 1940 | Boom Town | Square John Sand |
| 1940 | Edison, the Man | Thomas A. Edison |
| 1939 | Stanley and Livingstone | Henry M. Stanley |
| 1938 | Test Pilot | Gunner Morris |
| 1938 | Boys Town | Father Edward J. Flanagan |
| 1937 | Captains Courageous | Manuel Fidello |
| 1936 | San Francisco | Father Mullin |
| 1936 | Libeled Lady | Warren Haggerty |
| 1936 | Fury (1936) | Joe Wilson |
| 1935 | Dante's Inferno | Jim Carter |
| 1934 | Marie Galante | Dr. Crawbett |
| 1934 | Now I'll Tell | Murray Golden |
| 1934 | Bottoms Up | "Smoothie" King |
| 1933 | The Power and the Glory | Tom Garner |
| 1933 | Man's Castle | Bill |
| 1933 | Looking for Trouble | Joe Graham |
| 1933 | 20,000 Years in Sing Sing | Tommy Connors |
| 1933 | Face in the Sky | Joe Buck |
| 1933 | The Mad Game | Edward Carson |
| 1932 | The Painted Woman (1932) | Tom Brian |
| 1932 | Me and My Gal | Danny Dolan |
| 1932 | She Wanted a Millionaire | William Kelley |
| 1932 | Young America | Jack Doray |
| 1931 | Goldie (1931) | Bill |
| 1931 | Quick Millions | Daniel J. "Bugs" Raymond |
| 1930 | Up the River | Saint Louis |
