Filmography
| Year | Title | Role |
| 2024 | Thelma (2024) | Gail |
| 2023 | Beau is Afraid (2023) | Elaine |
| 2019 | The Booksellers (2020) | Executive Producer, Self |
| 2018 | The Con is On | Gina |
| 2017 | Columbus | Eleanor |
| 2016 | The Architect (2006) | Drew |
| 2016 | Café Society | Rad |
| 2016 | Mascots | Cindi Babineaux |
| 2016 | My Art | Angie |
| 2015 | Ned Rifle | Fay Grim |
| 2015 | Irrational Man | Rita |
| 2014 | Grace de Monaco | Madge Tivey-Faucon |
| 2012 | Price Check | Susan Felders |
| 2012 | And Now a Word From Our Sponsor | Karen Hillridge |
| 2012 | Hemingway et Gellhorn | Mary |
| 2011 | Inside Out (2011) | Claire Small |
| 2011 | Grab | Narrator |
| 2009 | Spring Breakdown | Becky |
| 2009 | Happy Tears | Jayne |
| 2008 | The Eye (2008) | Helen |
| 2007 | Broken English | Nora Wilder |
| 2006 | The Oh in Ohio | Priscilla Chase |
| 2006 | Superman Returns | Kitty Kowalski |
| 2006 | For Your Consideration | Callie Webb |
| 2006 | Fay Grim | Fay Grim |
| 2005 | Adam & Steve | Rhonda |
| 2004 | Laws of Attraction | Serena |
| 2004 | Blade: Trinity | Danica |
| 2003 | A Mighty Wind | Sissy Knox |
| 2003 | The Event | Nick |
| 2002 | The Sweetest Thing | Judy |
| 2002 | Personal Velocity | Greta |
| 2001 | Josie and the Pussycats | Fiona |
| 2001 | The Anniversary Party | Judy Adams |
| 2000 | Scream 3 | Jennifer Jolie/Gale in Stab 3 |
| 2000 | Best in Show | Meg Swan |
| 1998 | You've Got Mail | Patricia Eden |
| 1997 | Clockwatchers | Margaret Burre |
| 1997 | Henry Fool | Fay Grim |
| 1997 | The House of Yes | Jackie-O |
| 1996 | Waiting for Guffman | Libby Mae Brown |
| 1996 | Basquiat | Mary Boone |
| 1996 | The Daytrippers | Jo Malone |
| 1995 | The Doom Generation (1995) | Brandi |
| 1995 | Kicking and Screaming | Miami |
| 1995 | Flirt | Actor |
| 1993 | Dazed and Confused 30th Anniversary (2024) | Darla Marks |
