Filmography
| Year | Title | Role |
| 2024 | Parthenope (2025) | John Cheever |
| 2023 | Oppenheimer (2023) | Harry Truman |
| 2021 | Crisis (2021) | Dr. Tyrone Brower |
| 2021 | Exposing Muybridge (2022) | Self |
| 2020 | Mank (2020) | Herman J. Mankiewicz |
| 2019 | Killers Anonymous | The Man |
| 2019 | Mary (2019) | David |
| 2019 | The Laundromat (2019) | Jürgen Mossack |
| 2019 | The Courier (2019) | Ezekiel Mannings |
| 2019 | The Bayou (2025) | Tickle |
| 2018 | Hunter Killer (2018) | CJCS Charles Donnegan |
| 2017 | The Space Between Us | Nathaniel Shepherd |
| 2017 | The Hitman's Bodyguard | Vladislav Dukhovich |
| 2017 | Darkest Hour | Winston Churchill |
| 2016 | Criminal (2016) | Quaker Wells |
| 2015 | Child 44 | Gen. Mikhail Nesterov |
| 2015 | Man Down | Counselor Peyton |
| 2014 | RoboCop (2014) | Dr. Dennett Norton |
| 2014 | Dawn of the Planet of the Apes | Dreyfus |
| 2012 | The Dark Knight Rises | Commissioner Jim Gordon |
| 2012 | Lawless (2012) | Floyd Banner |
| 2012 | Guns, Girls and Gambling | Elvis |
| 2011 | Kung Fu Panda 2 | Shen |
| 2011 | Harry Potter and the Deathly Hallows Part 2: An IMAX 3D Experience | Sirius Black |
| 2011 | Red Riding Hood | Father Solomon |
| 2011 | Tinker Tailor Soldier Spy | George Smiley |
| 2010 | The Book of Eli | Carnegie |
| 2010 | Countdown to Zero | Narrator |
| 2009 | Disney's A Christmas Carol | Bob Cratchit/Marley/Tiny Tim |
| 2009 | Planet 51 | Gen. Grawl |
| 2009 | The Unborn | Rabbi Sendak |
| 2008 | The Dark Knight | Gordon |
| 2007 | Harry Potter and the Order of the Phoenix | Sirius Black |
| 2005 | Batman Begins | Lt. James Gordon |
| 2005 | Harry Potter and the Goblet of Fire 20th Anniversary (Fathom 2025) | Sirius Black |
| 2004 | Harry Potter and the Prisoner of Azkaban (2004) | Sirius Black |
| 2003 | Tiptoes | Rolfe |
| 2002 | Interstate 60 | O.W. Grant |
| 2001 | Hannibal | Mason Verger |
| 2000 | The Contender | Shelly Runyon |
| 1998 | Quest for Camelot | Ruber |
| 1998 | Lost in Space | Base Physician Zachary Smith, Ph.D. |
| 1997 | The Fifth Element | Jean-Baptiste Emmanuel Zorg |
| 1997 | Air Force One | Ivan Korshunov |
| 1997 | Nil by Mouth | Director, Producer, Writer |
| 1996 | Basquiat | Albert Milo |
| 1995 | The Scarlet Letter (1926) | Rev. Arthur Dimmesdale |
| 1994 | Immortal Beloved | Ludwig van Beethoven |
| 1994 | Leon | Stansfield |
| 1993 | True Romance | Drexl Spivey |
| 1992 | Bram Stoker's Dracula | Prince Vlad Dracula |
| 1991 | JFK | Lee Harvey Oswald |
| 1990 | State of Grace (1990) | Jackie Flannery |
| 1990 | Rosencrantz and Guildenstern Are Dead | Rosencrantz |
| 1988 | We Think the World of You | Johnny |
| 1987 | Prick Up Your Ears | Joe Orton |
| 1986 | Sid & Nancy | Sid Vicious |
| 1983 | Meantime (1983) | Coxy |
