- George Clooney
- Everett Ulysses McGill
- John Turturro
- Pete Hogwallop
- Tim Blake Nelson
- Delmar O'Donnel
- John Goodman
- Big Dan Teague
- Holly Hunter
- Penny
- Chris Thomas King
- Tommy Johnson, Original Songs
- Charles Durning
- Governor Pappy O'Daniel
- Del Pentecost
- Junior O'Daniel
- Michael Badalucco
- George "Babyface" Nelson
- J.R. Horne
- Pappy's Staff
- Brian Reddy
- Pappy's Staff
- Wayne Duvall
- Homer Stokes
- Ed Gale
- Little Man
- Ray McKinnon
- Vernon T. Waldrip
- Daniel von Bargen
- Sheriff Cooley
- Royce D. Applegate
- Man with Bullhorn
- Frank Collison
- Wash Hogwallop
- Quinn Gasaway
- Boy Hogwallop
- Lee Weaver
- Blind Seer
- Milford Fortenberry
- Pomade Vendor
- Stephen Root
- Radio Station Man
- John Locke
- Mr. French
- Gillian Welch
- Soggy Bottom Customer
- A. Ray Ratliff
- Record Store Clerk
- Mia Tate
- Siren
- Musetta Vander
- Siren
- Christy Taylor
- Siren
- April Hardcastle
- Waitress
- Michael W. Finnell
- Interrogator
- Georgia Rae Rainer
- Wharvey Gal
- Joel Coen
- Director, Film Editing, Writer
- Ethan Coen
- Film Editing, Producer, Writer
- Tim Bevan
- Executive Producer
- Eric Fellner
- Executive Producer
- John Cameron
- Co-Producer
- Robert Graf
- Associate Producer
- T Bone Burnett
- Original Music
- Carter Burwell
- Additional Music
- Chris Thomas King
- Tommy Johnson, Original Songs
- Roger Deakins
- Cinematographer
- Tricia Cooke
- Film Editing
- Ellen Chenoweth
- Casting
- Dennis Gassner
- Production Design
- Richard L. Johnson
- Art Director
- Nancy Haigh
- Set Decoration
- Mary Zophres
- Costume Design
