Despite underwhelming worldwide box office numbers for Scream 4, Wes Craven has said that Scream 5 is very likely to happen. In an interview with Movieweb, Craven said that Scream 4 was intended to be the start of a new trilogy of Scream movies.

"The odds are that there will be a Scream 5. It is something that Bob Weinstein wants to do. He tends to do what he wants to do. So I am inclined to think that there will be another sequel. Whether I will be a part of it or not? I don’t know. My contract gives me a first look. If they show me something that is really wonderful? Of course I will be a part of it."
 
Without giving too much away, Scream 4 ends with a rather open and ambiguous conclusion and doesn’t really give a fifth Scream movie a clear direction.
 
"Going into Scream 4, the first meeting I had with (writer) Kevin Williamson, he did sketch out a Scream 5 and 6. The idea was that we were doing the first in a new trilogy. We had to wait and see if we made enough money on each film to make the next one viable."
Scream 4 fell short of $100 million worldwide (and Harvey Weinstein’s projected $110 million pull), with a cumulative box office gross of $97 million. With a $40 million budget and significant marketing leading up to the movie’s release, Scream 4 barely broke even.
 
They’ll look to make up for the lackluster box office performance as the DVD and Blu-Ray arrives in stores Oct. 4.
 
Movie fans, are you interested in seeing a fifth Scream or has this franchise pretty much worn out its welcome?