- Anthony Hopkins
- Hannibal Lecter
- Julianne Moore
- Clarice Starling
- Gary Oldman
- Mason Verger
- Ray Liotta
- Paul Krendler
- Frankie R. Faison
- Barney
- Giancarlo Giannini
- Rinaldo Pazzi
- Francesca Neri
- Laura Pazzi
- Željko Ivanek
- Dr. Cordell Doemling
- Hazelle Goodman
- Evelda Drumgo
- David Andrews
- FBI Agent Pearsall
- Francis Guinan
- FBI Director Noonan
- James Opher
- DEA Agent Eldridge
- Enrico Lo Verso
- Gnocco
- Ivano Marescotti
- Carlo Deogracias
- Fabrizio Gifuni
- Matteo
- Alex Corrado
- Piero
- Marco Greco
- Tommaso
- Robert Rietti
- Sogliato
- Terry Serpico
- Officer Bolton
- Boyd Kestner
- Agent Mendez
- Peter Shaw
- Special Agent Brigham
- Kent Linville
- FBI Mail Boy
- Don McManus
- Asst. Mayor Benny Holcombe
- Harold Ginn
- Larkin Wayne
- Ted Koch
- BATF Agent Sneed
- William Powell-Blair II
- FBI Agent
- Aaron Craig
- 'Il Mostro' Detective
- Andrea Piedimonte
- Agent Benetti
- Ennio Coltorti
- Ricci
- Ian Iwataki
- Young Boy in Plane
- Mark Margolis
- Perfume Expert
- Ridley Scott
- Director, Producer
- Thomas Harris
- Writer
- David Mamet
- Writer
- Steven Zaillian
- Writer
- Dino De Laurentiis
- Executive Producer, Producer
- Martha De Laurentiis
- Producer
- Klaus Badelt
- Original Music
- Hans Zimmer
- Original Music
- John Mathieson
- Cinematographer
- Pietro Scalia
- Film Editing
- Greg Cannom
- Special Makeup Effects Artist
- David Crank
- Art Director
- Elaine L. Offers
- Makeup Artist
- Pamela Hochschartner
- Unit Production Manager
- Emma Horton
- Third Assistant Director
- Alberto Mangiante
- Second Assistant Director
- David A. Cohen
- Dialogue Editor
- Peter Staubli
- Sound Editor
- Norris Spencer
- Production Design
- Marco Allegri
- Set Decoration
- Crispian Sallis
- Set Decoration
- Janty Yates
- Costume Design
- Louis DiGiaimo
- Casting
