- Benicio del Toro
- Ernesto 'Che' Guevara de la Serna, Producer
- Demián Bichir
- Fidel Castro
- Santiago Cabrera
- Camillo Cienfuegos
- Elvira Mínguez
- Celia Sanchez
- Franka Potente
- Tania
- Jorge Perugorría
- Joaquin
- Edgar Ramírez
- Ciro Redondo
- Victor Rasuk
- Rogelio Acevedo
- Armando Riesco
- Benigno
- Catalina Sandino Moreno
- Aleida Guevara
- Rodrigo Santoro
- Raul Castro
- Unax Ugalde
- Little Cowboy
- Yul Vazquez
- Alejandro Ramirez
- Carlos Bardem
- Moises Guevara
- Joaquim de Almeida
- Barrientos
- Lou Diamond Phillips
- Mario Monje
- Julia Ormond
- Lisa Howard
- Kahlil Mendez
- Urbano
- Jordi Mollà
- Capt. Vargas
- Steven Soderbergh
- Cinematographer, Director
- Peter Buchman
- Writer
- Benjamin A. Van der Veen
- Writer
- Ernesto "Che" Guevara
- Writer
- Laura Bickford
- Producer
- Benicio del Toro
- Ernesto 'Che' Guevara de la Serna, Producer
- Belén Atienza
- Executive Producer
- Álvaro Augustin
- Executive Producer
- Frederic W. Brost
- Executive Producer
- Brahim Chioua
- Executive Producer
- Pablo Zumárraga
- Film Editing
- Alberto Iglesias
- Original Music
- Antxón Gómez
- Production Design
- Philip Messina
- Production Design
- María Clara Notari
- Art Director
- Pilar Revuelta
- Set Decoration
- Bina Daigeler
- Costume Design
- Rodrigo Bellott
- Casting
- J.C. Cantu
- Casting
- Carla Hool
- Casting
- Suzanne Smith
- Casting
- Eva Leira
- Casting
- Yolanda Serrano
- Casting
- Mary Vernieu
- Casting
