- Kyle MacLachlan
- Paul Atreides
- Sting
- Feyd-Rautha
- Francesca Annis
- Lady Jessica
- Leonardo Cimino
- The Baron's Doctor
- Brad Dourif
- Piter DeVries
- José Ferrer
- Padishah Emperor Shaddam IV
- Linda Hunt
- Shadout Mapes
- Freddie Jones
- Thufir Hawat
- Richard Jordan
- Duncan Idaho
- Virginia Madsen
- Princess Irulan
- Silvana Mangano
- Reverend Mother Ramallo
- Everett McGill
- Stilgar
- Kenneth McMillan
- Baron Vladimir Harkonnen
- Jack Nance
- Nefud
- Sîan Phillips
- Rev. Mother Gaius Helen Mohiam
- Jürgen Prochnow
- Duke Leto Atreides
- Paul L. Smith
- The Beast Rabban
- Patrick Stewart
- Gurney Halleck
- Dean Stockwell
- Doctor Wellington Yueh
- David Lynch
- Director
- Frank Herbert
- Writer
- Dino De Laurentiis
- Executive Producer
- Raffaella De Laurentiis
- Producer
- José López Rodero
- Associate Producer
- Brian Eno
- Original Music
- Roger Eno
- Original Music
- Daniel Lanois
- Original Music
- Steve Lukather
- Original Music
- David Paich
- Original Music
- Marty Paich
- Original Music
- Jeff Porcaro
- Original Music
- Mike Porcaro
- Original Music
- Steve Porcaro
- Original Music
- Joseph Williams
- Original Music
- Fred Francis
- Cinematographer
- Antony Gibbs
- Film Editing
- Jane Jenkins
- Casting
- Anthony Masters
- Production Design
- Benjamín Fernández
- Art Director
- Pier Luigi Basile
- Art Director
- Steve Cooper
- Set Decoration
- Giorgio Desideri
- Set Decoration
- Bob Ringwood
- Costume Design
- Mirella DeRossi
- Key Hair Stylist
- Ignazio Dolce
- Second Unit Director
