- Sam Worthington
- Perseus
- Liam Neeson
- Zeus
- Ralph Fiennes
- Hades
- Jason Flemyng
- Calibos/King Acrisius
- Gemma Arterton
- Io
- Alexa Davalos
- Andromeda
- Tine Stapelfeldt
- Danae
- Mads Mikkelsen
- Draco
- Luke Evans
- Apollo
- Izabella Miko
- Athena
- Liam Cunningham
- Solon
- Hans Matheson
- Ixas
- Ashraf Barhom
- Ozal
- Mouloud Achour
- Kucuk
- Ian Whyte
- Sheikh Sulieman
- Nicholas Hoult
- Eusebios
- Vincent Regan
- Kepheus
- Polly Walker
- Cassiopeia
- Katherine Loeppky
- Aged Cassiopeia
- Luke Treadaway
- Prokopion
- Pete Postlethwaite
- Spyros
- Elizabeth McGovern
- Marmara
- Alexander Siddig
- Hermes
- Tamer Hassan
- Ares
- Danny Huston
- Poseidon
- Louis Leterrier
- Director
- Travis Beacham
- Screenwriter
- Phil Hay
- Screenwriter
- Matt Manfredi
- Screenwriter
- Basil Iwanyk
- Producer
- Kevin De La Noy
- Producer
- Richard D. Zanuck
- Executive Producer
- Thomas Tull
- Executive Producer
- Jon Jashni
- Executive Producer
- William Fay
- Executive Producer
- Peter Menzies Jr.
- Cinematographer
- Martin Laing
- Production Design
- Vincent Tabaillon
- Film Editing
- Martin Walsh
- Film Editing
- Lindy Hemming
- Costume Design
- Ramin Djawadi
- Original Music
- Lucinda Syson
- Casting
- Elaine Grainger
- Casting
- Troy Sizemore
- Supervising Art Direction
- Gary Freeman
- Supervising Art Direction
- Anna Pinnock
- Set Decoration
- Ross Bradshaw
- Art Director
- James Foster
- Art Director
- Patricio M. Farrell
- Art Director
- Peter Russell
- Art Director
