- Bruce Willis
- Harry S. Stamper
- Billy Bob Thornton
- Dan Truman, NASA Administrator
- Liv Tyler
- Grace Stamper
- Ben Affleck
- A.J. Frost
- Will Patton
- Charles "Chick" Chapple
- Peter Stormare
- Lev Andropov, Russian Cosmonaut
- Keith David
- Lt. General Kimsey
- Steve Buscemi
- Rockhound
- Owen Wilson
- Oscar Choi, Geologist
- William Fichtner
- Colonel William Sharp, Shuttle Freedom Pilot
- Jessica Steen
- Jennifer Watts, Shuttle Freedom Co-Pilot
- Jason Isaacs
- Dr. Ronald Quincy, Research
- Ken Campbell
- Max Lennert
- Grayson McCouch
- Gruber
- Clark Brolly
- Freddy Noonan
- Marshall R. Teague
- Colonel Davis
- Chris Ellis
- Walter Clark
- Eddie Griffin
- Little Guy
- Michael Clarke Duncan
- Jayotis "Bear" Kurleenbear
- John Mahon
- Karl
- Grace Zabriskie
- Dottie
- Udo Kier
- Psychologist
- Seiko Matsuda
- Asian Tourist
- Lawrence Tierney
- Hollis Vernon Grap Stamper
- Michael Bay
- Director, Producer
- Robert Roy Pool
- Writer
- Tony Gilroy
- Writer
- Shane Salerno
- Writer
- Jonathan Hensleigh
- Executive Producer, Writer
- J.J. Abrams
- Writer
- Gale Anne Hurd
- Producer
- Jerry Bruckheimer
- Producer
- Chad Oman
- Executive Producer
- Jim Van Wyck
- Executive Producer
- John Schwartzman
- Cinematographer
- Mark Goldblatt
- Film Editing
- Chris Lebenzon
- Film Editing
- Glen Scantlebury
- Film Editing
- Trevor Rabin
- Original Music
- Michael White
- Production Design
- Lawrence A. Hubbs
- Art Director
- Bruton Jones
- Art Director
- Rick Simpson
- Set Decoration
- Magali Guidasci
- Costume Design
- Michael Kaplan
- Costume Design
- Bonnie Timmermann
- Casting
