- Will Smith
- Cassius Clay/Muhammad Ali
- Jamie Foxx
- Drew "Bundini" Brown
- Jon Voight
- Howard Cosell
- Mario Van Peebles
- Malcolm X
- Ron Silver
- Angelo Dundee
- Jeffrey Wright
- Howard Bingham
- Mykelti Williamson
- Don King
- Jada Pinkett Smith
- Sonji
- Michael Michele
- Veronica
- Joe Morton
- Chauncy Eskridge
- Paul Rodriguez
- Dr. Ferdie Pacheco
- Bruce McGill
- Bradley
- Barry Shabaka Henley
- Herbert Muhammad
- Giancarlo Esposito
- Cassius Clay, Sr.
- Laurence Mason
- Luis Sarria
- LeVar Burton
- Martin Luther King, Jr.
- Albert Hall
- Elijah Muhammad
- David Cubitt
- Robert Lipsyte
- Ted Levine
- Joe Smiley
- David Elliott
- Sam Cooke
- Shari Watson
- Woman Singer
- Malick Bowens
- Joseph Mobutu
- Michael Bentt
- Sonny Liston
- Alfred Cole
- Ernie Terrell
- Charles Shufford
- George Foreman
- Michael Mann
- Director, Producer, Screenwriter
- Stephen J. Rivele
- Screenwriter
- Christopher Wilkinson
- Screenwriter
- Eric Roth
- Screenwriter
- Gregory Allen Howard
- Writer
- A. Kitman Ho
- Producer
- Paul Ardaji
- Producer
- Jon Peters
- Producer
- James Lassiter
- Producer
- Emmanuel Lubezki
- Cinematographer
- John Myhre
- Production Design
- William Goldenberg
- Film Editing
- Stephen Rivkin
- Film Editing
- Lynzee Klingman
- Film Editing
- Marlene Stewart
- Costume Design
- Howard Bingham
- Executive Producer
- Graham King
- Executive Producer
- Lisa Gerrard
- Original Music
- Pieter Bourke
- Original Music
- Victoria Thomas
- Casting
- Bill Rea
- Art Director
- Tomas Voth
- Art Director
- Jim Erickson
- Set Decoration
