- Kurt Russell
- Wyatt Earp
- Val Kilmer
- Doc Holliday
- Michael Biehn
- Johnny Ringo
- Powers Boothe
- Curly Bill Brocious
- Robert John Burke
- Frank McLaury
- Dana Delany
- Josephine Marcus
- Sam Elliott
- Virgil Earp
- Stephen Lang
- Ike Clanton
- Terry O'Quinn
- Mayor John Clum
- Joanna Pacula
- Kate
- Bill Paxton
- Morgan Earp
- Jason Priestley
- Deputy Billy Breckinridge
- Michael Rooker
- Sherman McMasters
- Jon Tenney
- John Behan, Cochise County Sheriff
- Dana Wheeler-Nicholson
- Mattie Blaylock Earp, aka Celia Maddon
- Billy Zane
- Mr. Fabian
- Buck Taylor
- Turkey Creek Jack Johnson
- Harry Carey Jr.
- Tombstone Marshal Fred White
- Pedro Armendáriz Jr.
- The priest
- Charlton Heston
- Henry Hooker
- Robert Mitchum
- Billy Bob Thornton
- Johnny Tyler (faro dealer at Oriental Saloon)
- George P. Cosmatos
- Director
- Kevin Jarre
- Screenwriter
- Sean Daniel
- Producer
- James Jacks
- Producer
- Bob Misiorowski
- Producer
- Buzz Feitshans
- Executive Producer
- Andrew G. Vajna
- Executive Producer
- Bruce Broughton
- Original Music
- William A. Fraker
- Cinematographer
- Harvey Rosenstock
- Film Editing
- Roberto Silvi
- Film Editing
- Frank J. Urioste
- Film Editing
- Lora Kennedy
- Casting
- Catherine Hardwicke
- Production Design
- Chris Goran
- Art Director
- Kim Hix
- Art Director
- Mark Worthington
- Art Director
- Gene Serdena
- Set Decoration
