- Chris Pratt
- Emmet Brickowski/Rex Dangervest
- Elizabeth Banks
- Wyldstyle/Lucy
- Will Arnett
- Batman
- Tiffany Haddish
- Queen Watevra Wa'Nabi
- Stephanie Beatriz
- General Mayhem/Sweet Mayhem
- Alison Brie
- Unikitty/Ultrakatty
- Nick Offerman
- MetalBeard
- Charlie Day
- Benny
- Maya Rudolph
- Mom
- Will Ferrell
- President Business/Dad
- Jadon Sand
- Finn
- Brooklynn Prince
- Bianca
- Channing Tatum
- Superman
- Jonah Hill
- Green Lantern
- Richard Ayoade
- Ice Cream Cone
- Ben Schwartz
- Banarnar
- Noel Fielding
- Balthazar
- Jason Momoa
- Aquaman
- Cobie Smulders
- Wonder Woman
- Ike Barinholtz
- Lex Luthor
- Ralph Fiennes
- Alfred Pennyworth
- Will Forte
- Abraham Lincoln
- Jimmy O. Yang
- Enthusiastic Zebra
- Jorma Taccone
- Larry Poppins
- Bruce Willis
- Himself
- Gary Payton
- Himself
- Sheryl Swoopes
- Herself
- Todd Hansen
- Gandalf/Swamp Creature
- Doug Nicholas
- Surfer Dave/Chainsaw Dave/Purgatory Dave
- Liam Knight
- Duplo/Heart/Star/Sewer Babies
- Emmett Mitchell
- Duplo/Duplo Foreman/Duplo Wonder Woman
- Sawyer D. Jones
- Duplo/Heart/Star
- Graham Miller
- Duplo/Young Finn
- Cora Miller
- Duplo/Star
- Mike Mitchell
- Director
- Phil Lord
- Producer, Screenwriter
- Chris Miller
- Producer, Screenwriter
- Dan Lin
- Producer
- Roy Lee
- Producer
- Jinko Gotoh
- Producer
- Jill Wilfert
- Executive Producer
- Keith Malone
- Executive Producer
- Matthew Ashton
- Executive Producer
- Chris McKay
- Executive Producer
- Zareh Nalbandian
- Executive Producer
- Ryan Halprin
- Executive Producer
- Will Allegra
- Executive Producer
- Chris Leahy
- Executive Producer
- Clare Knight
- Film Editing
- Mark Mothersbaugh
- Original Music
- Patrick Marc Hanenberger
- Production Design
- Kristen Anderson
- Art Director
- Caroline Cranstoun
- Costume Design
- Mary Hidalgo
- Casting
