- Gary Cooper
- Howard Roark
- Patricia Neal
- Dominique Francon
- Raymond Massey
- Gail Wynand
- Kent Smith
- Peter Keating
- Robert Douglas
- Ellsworth Toohey
- Henry Hull
- Henry Cameron
- Ray Collins
- Roger Enright
- Moroni Olsen
- Chairman
- Jerome Cowan
- Alvah Scarret
- Paul Harvey
- Opera businessman (uncredited)
- Thurston Hall
- Businessman at party (uncredited)
- Harry Woods
- Quarry superintendent (uncredited)
- Paul Stanton
- Dean who expels Roark (uncredited)
- Bob Alden
- Newsboy (uncredited)
- Tristram Coffin
- Toohey's secretary (uncredited)
- Roy Gordon
- Vice-President (uncredited)
- Isabel Withers
- Secretary (uncredited)
- Almira Sessions
- Dominique's housekeeper at quarry (uncredited)
- Tito Vuolo
- Pasquale Orsini (uncredited)
- William Haade
- Worker (uncredited)
- Gail Bonney
- Woman (uncredited)
- Dorothy Christy
- Society woman (uncredited)
- Harlan Warde
- Young man (uncredited)
- Jonathan Hale
- Guy Francon (uncredited)
- Frank Wilcox
- Gordon Prescott (uncredited)
- Douglas Kennedy
- Reporter (uncredited)
- Pierre Watkin
- Cortlandt official (uncredited)
- Selmer Jackson
- Cortlandt official (uncredited)
- John Doucette
- Gus Webb (uncredited)
- John Alvin
- Young intellectual (uncredited)
- King Vidor
- Director
- Ayn Rand
- Writer
- Henry Blanke
- Producer
- Max Steiner
- Original Music
- L. Robert Burks
- Cinematographer
- David Weisbart
- Film Editing
- Edward Carrere
- Art Director
- William L. Kuehl
- Set Decoration
- Milo Anderson
- Costume Design
- Perc Westmore
- Makeup Artist
- Gertrude Wheeler
- Hair Stylist
- Eric Stacey
- Production Manager
- Richard Maybery
- Assistant Director
