- John Belushi
- Jake Blues
- Dan Aykroyd
- Elwood Blues, Writer
- James Brown
- Reverend Cleophus James
- Cab Calloway
- Curtis
- Ray Charles
- Ray
- Carrie Fisher
- Mystery Woman
- Aretha Franklin
- Mrs. Murphy
- Henry Gibson
- Head Nazi
- John Candy
- Burton Mercer
- Murphy Dunne
- Murph
- Steve Cropper
- Steve "The Colonel" Cropper
- Donald Dunn
- Donald "Duck" Dunn
- Willie Hall
- Willie "Too Big" Hall
- Tom Malone
- Tom "Bones" Malone
- Lou Marini
- "Blue" Lou Marini
- Matt Murphy
- Matt "Guitar" Murphy
- Frank Oz
- Corrections Officer
- Kathleen Freeman
- Sister Mary Stigmata
- Armand Cerami
- Trooper Daniel
- Steven Williams
- Trooper Mount
- Charles Napier
- Tucker McElroy
- Steve Lawrence
- Maury Sline
- Twiggy
- Chic Lady
- Steven Spielberg
- Cook County Assessor's Office Clerk
- John Landis
- Director, Writer
- Dan Aykroyd
- Elwood Blues, Writer
- Robert K. Weiss
- Producer
- Bernie Brillstein
- Executive Producer
- Stephen M. Katz
- Cinematographer
- George Folsey Jr.
- Film Editing
- Elmer Bernstein
- Original Music
- John J. Lloyd
- Production Design
- Henry Larrecq
- Art Director
- Hal Gausman
- Set Decoration
- Leslie McCarthy-Frankenheimer
- Set Decoration
- Deborah Nadoolman
- Costume Design
- Michael Chinich
- Casting
