- Antonio Banderas
- Gregorio Cortez
- Carla Gugino
- Ingrid Cortez
- Alexa PenaVega
- Carmen Cortez
- Daryl Sabara
- Juni Cortez
- Alan Cumming
- Fegan Floop
- Tony Shalhoub
- Alexander Minion
- Teri Hatcher
- Mrs. Gradenko
- Cheech Marin
- Felix Gumm
- Robert Patrick
- Mr. Lisp
- Danny Trejo
- Isidor 'Machete' Cortez
- Mike Judge
- Donnagon/Donnamight
- Richard Linklater
- Cool Spy
- Guillermo Navarro
- Pastor, Cinematographer
- Johnny Reno
- Agent Johnny
- Shannon Shea
- FoOglie No. 1/Flower
- Norman Cabrera
- FoOglie No. 2/Tall & Skinny
- Trant Batey
- FoOglie No. 3/Too Too
- Andy W. Bossley
- Brat
- J. J. Dashnaw
- Brat's Dad
- Kara Slack
- Carmen's Friend
- Ermahn Ospina
- Cab Driver
- Emilio Navarro Mackissack
- Excited Kid at Playground
- Evan Sabara
- Intruder Spy Kid
- Rachel Duhame
- President's Robot Daughter
- Houston Hooker
- Lisp's Robot Son
- Louis Black
- Financier
- Charles Ramirez-Berg
- Financier
- Dick Clark
- Financier
- Steve Havens
- Financier
- Roberto Santibanez
- Financier
- Robert Rodriguez
- Director, Film Editing, Original Music, Producer, Writer
- Elizabeth Avellan
- Producer
- Cary Granat
- Executive Producer
- Bill Scott
- Line Producer
- Bob Weinstein
- Executive Producer
- Harvey Weinstein
- Executive Producer
- Guillermo Navarro
- Pastor, Cinematographer
- Anne McCarthy
- Casting
- Mary Vernieu
- Casting
- Cary White
- Production Design
- Edward Vega
- Art Director
- Jeanette Scott
- Set Decoration
- Deborah Everton
- Costume Design
- John Debney
- Original Music
- Harry Gregson-Williams
- Original Music
- Gavin Greenaway
- Original Music
- Heitor Pereira
- Original Music
