- Tom Holland
- Peter Parker/Spider-Man
- Michael Keaton
- Adrian Toomes/Vulture
- Robert Downey Jr.
- Tony Stark/Iron Man
- Marisa Tomei
- May Parker
- Jon Favreau
- Happy Hogan
- Gwyneth Paltrow
- Pepper Potts
- Zendaya
- Michelle
- Donald Glover
- Aaron Davis
- Jacob Batalon
- Ned
- Laura Harrier
- Liz
- Tony Revolori
- Flash
- Bokeem Woodbine
- Herman Schultz/Shocker No. 2
- Tyne Daly
- Anne Marie Hoag
- Abraham Attah
- Abe
- Hannibal Buress
- Coach Wilson
- Kenneth Choi
- Principal Morita
- Selenis Leyva
- Ms. Warren
- Angourie Rice
- Betty
- Martin Starr
- Mr. Harrington
- Garcelle Beauvais-Nilon
- Doris Toomes
- Michael Chernus
- Phineas Mason/The Tinkerer
- Michael Mando
- Mac Gargan
- Logan Marshall-Green
- Jackson Brice/Shocker No. 1
- Jennifer Connelly
- Karen/Suit Lady
- Gary Weeks
- Agent Foster
- Christopher Berry
- Randy
- Jorge Lendeborg
- Jason
- Tunde Adebimpe
- Mr. Cobbwell
- Tiffany Espensen
- Cindy
- Isabella Amara
- Sally
- Michael Barbieri
- Charles
- Josie Totah
- Seymour
- Hemky Madera
- Mr. Delmar
- Jon Watts
- Director, Screenwriter
- Jonathan M. Goldstein
- Screenwriter
- John Francis Daley
- Screenwriter
- Christopher Ford
- Screenwriter
- Chris McKenna
- Screenwriter
- Erik Sommers
- Screenwriter
- Louis D'Esposito
- Executive Producer
- Victoria Alonso
- Executive Producer
- Patricia Whitcher
- Executive Producer
- Jeremy Latcham
- Executive Producer
- Stan Lee
- Executive Producer
- Avi Arad
- Executive Producer
- Matthew Tolmach
- Executive Producer
- Amy Pascal
- Producer
- Kevin Feige
- Producer
- Salvatore Totino
- Cinematographer
- Dan Lebental
- Film Editing
- Debbie Berman
- Film Editing
- Michael Giacchino
- Original Music
- Oliver Scholl
- Production Design
- Brad Ricker
- Art Director
- Beat Frutiger
- Art Director
- Lauren Abiouness
- Art Director
- Audra Avery
- Art Director
- Gene Serdena
- Set Decoration
- Louise Frogley
- Costume Design
- Sarah Halley Finn
- Casting
