- Jason Robards
- Earl Partridge
- Julianne Moore
- Linda Partridge
- Tom Cruise
- Frank T.J. Mackey
- Philip Seymour Hoffman
- Phil Parma
- John C. Reilly
- Jim Kurring
- Melora Walters
- Claudia Wilson Gator
- Jeremy Blackman
- Stanley Spector
- Michael Bowen
- Rick Spector
- William H. Macy
- Donnie Smith
- Philip Baker Hall
- Jimmy Gator
- Melinda Dillon
- Rose Gator
- Emmanuel Johnson
- Dixon
- Michael Murphy
- Alan Kligman
- Luis Guzmán
- April Grace
- Gwenovier
- Orlando Jones
- Worm
- Ricky Jay
- Burt Ramsey/Prologue Narrator
- Henry Gibson
- Thurston Howell
- Felicity Huffman
- Cynthia
- Alfred Molina
- Solomon Solomon
- Don McManus
- Dr. Landon
- Eileen Ryan
- Mary
- Danny Wells
- Dick Jennings
- Paul Thomas Anderson
- Director, Producer, Writer
- Michael De Luca
- Executive Producer
- Lynn Harris
- Executive Producer
- Daniel Lupi
- Co-Producer, Unit Production Manager
- JoAnne Sellar
- Producer
- Dylan Tichenor
- Film Editing
- Cassandra Kulukundis
- Casting
- Robert Elswit
- Cinematographer
- Fiona Apple
- Music
- Jon Brion
- Music
- Aimee Mann
- Songs
- William Arnold
- Production Design
- Mark Bridges
- Costume Design, Production Design
- Shepherd Frankel
- Art Director
- David Nakabayashi
- Art Director
- Chris Spellman
- Set Decoration
- Elaine L. Offers
- Makeup Artist
- Tina Roesler Kerwin
- Key Makeup Artist
- Craig Markey
- Production Supervisor
