- Bill Pullman
- Fred Madison
- Patricia Arquette
- Renee Madison/Alice Wakefield
- Balthazar Getty
- Pete Dayton
- Robert Blake
- Mystery Man
- Natasha Gregson Wagner
- Sheila
- Richard Pryor
- Arnie
- Michael Massee
- Andy
- Jack Nance
- Phil
- Jack Kehler
- Guard Johnny Mack
- Henry Rollins
- Guard Henry
- Gene Ross
- Warden Clements
- Scott Coffey
- Teddy
- Gary Busey
- Bill Dayton
- Robert Loggia
- Dick Laurent/Mr. Eddy
- John Roselius
- Al
- Louis Eppolito
- Det. Ed
- Michael Shamus Wiles
- Guard Mike
- Mink Stole
- Jury Forewoman
- Leonard Termo
- Judge
- Jenna Maetlind
- Party Girl
- Ivory Ocean
- Guard Ivory
- David Byrd
- Doctor Smordin
- F. William Parker
- Captain Luneau
- Guy Siner
- Man in Group at Office
- Alexander Folk
- Prison Official #2
- Lucy Butler
- Candace Dayton
- Carl Sundstrom
- Hank
- John Solari
- Lou
- Al Garrett
- Carl
- David Lynch
- Director, Writer
- Barry Gifford
- Writer
- Deepak Nayar
- Producer, Unit Production Manager
- Tom Sternberg
- Producer
- Mary Sweeney
- Film Editing, Producer
- Angelo Badalamenti
- Original Music
- Peter Deming
- Cinematographer
- Elaine Huzzar
- Casting
- Johanna Ray
- Casting
- Patricia Norris
- Costume Design, Production Design
- Leslie Morales
- Set Decoration
- Sabrina S. Sutherland
- Production Supervisor
