- Audrey Tautou
- Amelie
- Mathieu Kassovitz
- Nino Quicampoix
- Rufus
- Raphael Poulain (Amelie's father)
- Yolande Moreau
- Madeleine Wallace (concierge)
- Dominique Pinon
- Joseph
- Maurice Bénichou
- Dominique Bretodeau
- Claude Perron
- Eva (the strip teaser)
- Isabelle Nanty
- Georgette
- Claire Maurier
- Suzanne
- Clotilde Mollet
- Gina
- Serge Merlin
- Dufayel
- Jamel Debbouze
- Lucien
- Flora Guiet
- Amelie (8 years old)
- André Dussollier
- Narrator / Récitant
- Michel Robin
- Old Man Collignon
- Lorella Cravotta
- Amandine Poulain
- Armelle
- Philomene
- Ticky Holgado
- L'homme dans la photo
- Frankie Pain
- La marchande de journaux
- Jean Darie
- The Blind Man
- Jean-Pierre Jeunet
- Director, Writer
- Claudie Ossard
- Producer
- Christophe Vassort
- First Assistant Director
- Anne Wermelinger
- Script Supervisor
- Bruno Delbonnel
- Cinematographer
- Mathieu Junot
- Set Decoration
- Madeline Fontaine
- Costume Design
- Nathalie Tissier
- Makeup Artist
- Vèronique Boitout
- Hair Stylist
- Hervé Schneid
- Film Editing
- Gérard Hardy
- Sound Editor
- Céline Kélépikis
- Assistant Editor
- Pierre-Jacques Bénichou
- Casting
- Valérie Espagne
- Casting
- Yann Tiersen
- Original Music
- Volker Schäfer
- Art Director
- Alain Carsoux
- Visual Effects Supervisor
- Yves Domenjoud
- Special Effects Supervisor
- Jean Umansky
- Sound
- Thorsten Sabel
- Set Dresser
- Guillaume Laurant
- Screenwriter, Writer
