- Will Smith
- Captain Steven 'Eagle' Hiller
- Bill Pullman
- President Thomas J. Whitmore
- Jeff Goldblum
- David Levinson
- Mary McDonnell
- First Lady Marilyn Whitmore
- Judd Hirsch
- Julius Levinson
- Margaret Colin
- Constance Spano/Levinson
- Randy Quaid
- Russell Casse
- Robert Loggia
- U.S. Space Command General William Grey
- James Rebhorn
- Secretary of Defense Albert Nimzicki
- Harvey Fierstein
- Marty Gilbert
- Adam Baldwin
- Major Mitchell
- Brent Spiner
- Dr. Brakish Okun
- James Duval
- Miguel Casse
- Vivica A. Fox
- Jasmine Dubrow
- Lisa Jakub
- Alicia Casse
- Ross Bagley
- Dylan Dubrow
- Mae Whitman
- First Daughter Patricia Whitmore
- Bill Smitrovich
- Captain Watson
- Kiersten Warren
- Tiffany
- Harry Connick Jr.
- Captain Jimmy 'Raven' Wilder
- Christine Devine
- Video Newscaster
- Roland Emmerich
- Director, Executive Producer, Writer
- Dean Devlin
- Producer, Writer
- Ute Emmerich
- Executive Producer
- William Fay
- Executive Producer, Unit Production Manager
- Peter Winther
- Associate Producer
- David Arnold
- Original Music
- Karl Walter Lindenlaub
- Cinematographer
- David Brenner
- Film Editing
- Wendy Kurtzman
- Casting
- Oliver Scholl
- Art Director, Production Design
- Patrick Tatopoulos
- Production Design
- William James Teegarden
- Art Director
- Jim Erickson
- Set Decoration
- Joseph A. Porro
- Costume Design
- Kelly Van Horn
- Unit Production Manager
