- Gibson Gowland
- John McTeague
- ZaSu Pitts
- Trina
- Jean Hersholt
- Marcus Schuller
- Chester Conklin
- "Popper" Sieppe
- Sylvia Ashton
- Mommer' Sieppe
- Joan Standing
- Selina
- Tempe Pigott
- Mother McTeague
- Dale Fuller
- Maria Miranda Maccapa
- Oscar Gottell
- A Sieppe twin (uncredited)
- Otto Gottell
- A Sieppe twin (uncredited)
- Frank Hayes
- Charles W. Grannis (proprietor, The Modern Dog Hospital) (uncredited)
- Jack Curtis
- McTeague Sr. (shift boss at the Big Dipper Mine) (uncredited)
- James F. Fulton
- Cribbens (a prospector) (uncredited)
- Jack McDonald
- Placer County Sheriff (uncredited)
- Austen Jewell
- August Sieppe (uncredited)
- Cesare Gravina
- Zwerkow (a junkman) (uncredited)
- Erich von Stroheim
- Art Director, Director, Film Editing, Production Design, Writer
- Joseph Farnham
- Film Editing, Writer
- June Mathis
- Film Editing, Writer
- Frank Norris
- Writer
- Louis B. Mayer
- Executive Producer
- Irving Thalberg
- Producer
- Kevin Brownlow
- Producer
- David Gill
- Producer
- Carl Davis
- Original Music
- Robert Israel
- Original Music
- William H. Daniels
- Cinematographer
- Ben F. Reynolds
- Cinematographer
- Frank E. Hull
- Film Editing
- Rex Ingram
- Film Editing
- Grant Whytock
- Film Editing
- Richard Day
- Art Director
- Cedric Gibbons
- Art Director
