- Tim Allen
- Jason Nesmith/Commanter Peter Quincy Taggart
- Sigourney Weaver
- Gwen DeMarco/Lieutenant Tawny Madison
- Alan Rickman
- Sir Alexander Dane/Dr. Lazarus
- Tony Shalhoub
- Fred Kwan/Tech Sergeant Chen
- Sam Rockwell
- Guy Fleegman/Security Chief 'Roc' Ingersol
- Daryl "Chill" Mitchell
- Tommy Webber/Lieutenant Laredo
- Enrico Colantoni
- Mathesar
- Robin Sachs
- Sarris
- Patrick Breen
- Quellek
- Missi Pyle
- Laliari/Jane Doe
- Jed Rees
- Teb
- Justin Long
- Brandon
- Jeremy Howard
- Kyle
- Kaitlin Cullum
- Katelyn
- Jonathan Feyer
- Hollister
- Corbin Bleu
- Young Tommy Webber
- Wayne Pere
- Lieutenant Lathe
- Sam Lloyd
- Neru
- Bill Chott
- Fan
- Morgan Rusler
- Fan
- Gregg Binkley
- Fan
- Brandon Michael DePaul
- Fan
- Paul G. Kubiak
- Fan
- Greg Colbrook
- Fan
- Jennifer Manley
- Shy Girl
- John Patrick White
- Teen in the Bathroom
- Todd Giebenhain
- Teen in the Bathroom
- J.P. Manoux
- Excited Alien
- Dan Gunther
- Navigator
- Matt Winston
- Technician No. 1
- Brandon Keener
- Technician No. 2
- Dean Parisot
- Director
- David Howard
- Screenwriter, Writer
- Robert Gordon
- Screenwriter
- Elizabeth Cantillon
- Executive Producer
- Allegra Clegg
- Associate Producer
- Suzann Ellis
- Co-Producer
- Sona Gourgouris
- Co-Producer
- Mark Johnson
- Producer
- Charles Newirth
- Producer
- Steven Spielberg
- Executive Producer
- David Newman
- Original Music
- Jerzy Zielinski
- Cinematographer
- Don Zimmerman
- Film Editing
- Debra Zane
- Casting
- Linda DeScenna
- Production Design
- James Nedza
- Art Director
- Ric McElvin
- Set Decoration
- Albert Wolsky
- Costume Design
