- Eddie Murphy
- Prince Akeem/Clarence/Saul/Randy Watson, Producer
- Arsenio Hall
- Semmi/Morris/Reverend Brown/Baba
- Jermaine Fowler
- Lavelle Junson
- Leslie Jones
- Mary Junson
- Tracy Morgan
- Uncle Reem
- KiKi Layne
- Meeka
- Shari Headley
- Lisa
- Wesley Snipes
- General Izzi
- James Earl Jones
- King Jaffe Joffer
- John Amos
- Cleo McDowell
- Teyana Taylor
- Bopoto
- Vanessa Bell Calloway
- Imani Izzi
- Paul Bates
- Oha
- Nomzamo Mbatha
- Mirembe
- Bella Zahra Murphy
- Omma
- Louie Anderson
- Maurice
- Rick Ross
- Nexdorian Commander
- Luenell
- Livia
- Garcelle Beauvais-Nilon
- Rose Bearer Priestess
- Michael Blackson
- Nexdorian Lieutenant
- Craig Brewer
- Director
- Kenya Barris
- Executive Producer, Screenwriter
- Barry W. Blaustein
- Screenwriter
- David Sheffield
- Screenwriter
- Kevin Misher
- Producer
- Eddie Murphy
- Prince Akeem/Clarence/Saul/Randy Watson, Producer
- Brian Oliver
- Executive Producer
- Bradley J. Fischer
- Executive Producer
- Valerii An
- Executive Producer
- Charisse M. Hewitt
- Executive Producer
- Michele Imperato
- Executive Producer
- Joe "Jody" Williams
- Cinematographer
- Billy Fox
- Film Editing
- Debra Neil-Fisher
- Film Editing
- Jermaine Stegall
- Original Music
- Jefferson Sage
- Production Design
- Kristen Sherwin
- Art Director
- Douglas A. Mowat
- Set Decoration
- Ruth E. Carter
- Costume Design
- Leah Daniels
- Casting
- George Pierre
- Casting
