- Tom Hanks
- Zachry
- Halle Berry
- Luisa Rey
- Jim Broadbent
- Timothy Cavendish
- Hugo Weaving
- Nurse Noakes
- Jim Sturgess
- Adam Ewing
- Bae Doona
- Sonmi-451
- Ben Whishaw
- Robert Frobischer
- James D'Arcy
- Rufus Sixsmith
- Susan Sarandon
- Madame Horrox
- Hugh Grant
- Kona Chief
- Keith David
- Joe Napier
- Xun Zhou
- Yoona-939
- David Gyasi
- Autua
- Robert Fyfe
- Old Salty Dog
- Martin Wuttke
- Mr. Boerhaave
- Robin Morrissey
- Young Cavendish
- Brody Nicholas Lee
- Javier Gomez
- Lana Wachowski
- Director, Producer, Screenwriter
- Lilly Wachowski
- Director, Producer, Screenwriter
- Tom Tykwer
- Director, Original Music, Producer, Screenwriter
- Grant Hill
- Producer
- Stefan Arndt
- Producer
- Philip Lee
- Executive Producer
- Uwe Schott
- Executive Producer
- Wilson Qiu
- Executive Producer
- John Toll
- Cinematographer
- Frank Griebe
- Cinematographer
- Uli Hanisch
- Production Design
- Hugh Bateup
- Production Design
- Alexander Berner
- Film Editing
- Johnny Klimek
- Original Music
- Reinhold Heil
- Original Music
- Kym Barrett
- Costume Design
- Pierre-Yves Gayraud
- Costume Design
- Stephan O. Gessler
- Supervising Art Direction
- Kai Koch
- Supervising Art Direction
- Charlie Revai
- Supervising Art Direction
- Rebecca Alleway
- Set Decoration
- Peter Walpole
- Set Decoration
- Lora Kennedy
- Casting
- Lucinda Syson
- Casting
- Gigi Oeri
- Associate Producer
