- Angelina Jolie
- Christine Collins
- John Malkovich
- Rev. Gustav Briegleb
- Jeffrey Donovan
- Capt. J.J. Jones
- Michael Kelly
- Det. Lester Ybarra
- Colm Feore
- Chief James E. Davis
- Jason Butler Harner
- Gordon Northcott
- Amy Ryan
- Carol Dexter
- Geoff Pierson
- S.S. Hahn
- Denis O'Hare
- Dr. Jonathan Steele
- Frank Wood
- Ben Harris
- Peter Gerety
- Dr. Earl W. Tarr
- Reed Birney
- Mayor Cryer
- Gattlin Griffith
- Walter Collins
- Devon Conti
- Arthur Hutchins
- Eddie Alderson
- Sanford Clark
- Dale Dickey
- Patiente
- Michelle Gunn
- Sandy
- Jan Devereaux
- Operator
- Erica Grant
- Operator
- Antonia Bennett
- Operator
- Kerri Randles
- Operator
- Morgan Eastwood
- Girl on Tricycle
- Madison Hodges
- Neighborhood Girl
- Ric Sarabia
- Man at Diner
- J.P. Bumstead
- Cook
- Debra Christofferson
- Police Matron at Train
- Russell Edge
- Reporter at Train
- John Harrington Bland
- Dr. John Montgomery
- Pamela Dunlap
- Mrs. Fox
- Roger Hewlett
- Officer Morelli
- Jim Cantafio
- Desk Sergeant
- Maria Rockwell
- Police Matron at Precinct
- Wendy Worthington
- Reception Nurse
- Riki Lindhome
- Examination Nurse
- Sterling Wolfe
- Briegleb's Aide
- Michael McCafferty
- Ticket Vendor
- David Goldman
- Administrator
- Anthony De Marco
- Abducted Kid
- Joshua Moore
- Abducted Kid
- Muriel Minot
- Secretary
- Kevin Glikmann
- Male Orderly
- Hope Shapiro
- Medication Nurse
- Caleb Campbell
- Backup Detective
- Jeff Cockey
- Backup Detective
- Clint Eastwood
- Director
- J. Michael Straczynski
- Screenwriter
- Brian Grazer
- Producer
- Ron Howard
- Producer
- Robert Lorenz
- Producer
- Tim Moore
- Executive Producer
- James Whitaker
- Executive Producer
- Tom Stern
- Cinematographer
- Joel Cox
- Film Editing
- Gary D. Roach
- Film Editing
- James J. Murakami
- Production Design
- Patrick M. Sullivan Jr.
- Art Director
- Gary Fettis
- Set Decoration
- Deborah Hopper
- Costume Design
- Ellen Chenoweth
- Casting
