- Jake Gyllenhaal
- Jimmy Livingston
- Swoosie Kurtz
- Mrs. Livingston
- Marley Shelton
- Chloe
- Danny Trejo
- Slim
- John Carroll Lynch
- Mr. Livingston
- Verne Troyer
- Dr. Phreak
- Dave Sheridan
- Mark
- Brian George
- Pushpak
- Patrick Cranshaw
- Pappy/Pippy
- Stephen Spinella
- Chicken Man
- Ever Carradine
- Mark's Sister
- Geoffrey Arend
- Flipper Boy
- Beetlejuice
- Li'l Zip
- Matthew McGrory
- Human Sasquatch
- Bonnie Morgan
- Rubber Woman
- Jason Sklar
- Shlomo
- Fabio
- Gil
- Ping Wu
- Emcee
- Zach Galifianakis
- Bus Stop Man
- Boti Bliss
- Cashier
- Pablo Schreiber
- Todd
- Brian Gattas
- Todd
- Cinco Paul
- Todd, Writer
- Ken Daurio
- Todd, Writer
- Malik Toure
- Todd
- Leo Fitzpatrick
- Todd
- J.P. Coe
- Todd
- R.J. Durell
- Todd
- Brian Friedman
- Todd
- Arden Myrin
- Lorraine
- Blair Hayes
- Director
- Beau Flynn
- Producer
- Eric McLeod
- Executive Producer
- Cinco Paul
- Todd, Writer
- Ken Daurio
- Todd, Writer
- Jerzy Zielinski
- Cinematographer
- Barry Ray Robison
- Production Design
- Pamela Martin
- Film Editing
- Christopher Lawrence
- Costume Design
- John Houlihan
- Music Supervisor
- John Ottman
- Original Music
- John Papsidera
- Casting
- Katherine E. Beyda
- Unit Production Manager
- Michael Amundson
- First Assistant Director
- Troy Sizemore
- Art Director
- Christa Munro
- Art Director
- Garrett Lewis
- Set Decoration
- Gigi Williams
- Key Makeup Artist
- Shari Perry
- Key Hair Stylist
- Ketty Gonzalez
- Hair Stylist
